Cognitive outcome as part and parcel of clinical outcome in brain tumor surgery
Although validated tools (neuropsychological tests, patient reported outcomes, mood and psychological profile) were first introduced many years ago in clinical practice, the impact of the tumor itself on patient cognition has not been extensively studied. Furthermore, while outcome research is evolving in an attempt to adapt the use of different tools to the preoperative and postoperative phases, the standard guidelines for evaluating outcome after brain surgery, by neurological examination and complication assessment, are frequently neglected in the current literature. This article attempts to provide an appraisal of the evidence for the impact of surgical treatment on cognitive function of brain tumor patients within the context of general outcome.
KeywordsBrain tumors Surgical treatment Clinical assessment Cognitive assessment
Conflict of interest
The authors declare that they have no conflict of interest.
- 2.Duffau H, Lopes M, Arthuis F, Bitar A, Sichez JP, Van Effenterre R, Capelle L (2005) Contribution of intraoperative electrical stimulation in surgery of low-grade gliomas: a comparative study between two series without (1985–1996) and with (1996–2003) functional mapping in the same situation. J Neurol Neurosurg Psychiatry 76:845–851PubMedCrossRefGoogle Scholar
- 5.Karnofsky DA, Burcheral JH (1949) The clinical evaluation of chemotherapeutic agents in cancer. In: McLeod CM (ed) Evaluation of chemotherapeutic agents. Columbia University Press, New York, pp 191–205Google Scholar
- 13.Chang SM, Parney IF, McDermott M, Barker FG 2nd, Schmidt MH, Huang W, Laws ER Jr, Lillehei KO et al (2003) Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project. J Neurosurg 98:1175–1181PubMedCrossRefGoogle Scholar
- 18.Buckner JC, Schomberg PJ, McGinnis WL, Cascino TL, Scheithauer BW, O’Fallon JR, Morton RF, Kuross SA et al (2001) A phase III study of radiation therapy plus carmustine with or without recombinant interferon-alpha in the treatment of patients with newly diagnosed high-grade glioma. Cancer 92:420–433PubMedCrossRefGoogle Scholar
- 23.World Health Organization (2001) International classification of functioning, disability, and health. World Health Organization, GenevaGoogle Scholar
- 30.Souhami L, Seiferheld W, Brachman D et al (2004) Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93–05 protocol. Int J Radiat Oncol Biol Phys 60:853–860PubMedCrossRefGoogle Scholar
- 37.Kiebert GM, Curran D, Aaronson NK et al (1998) Quality of life after radiation therapy of cerebral low-grade gliomas of the adult: results of a randomised phase III trial on dose response (EORTC trial 22844). EORTC Radiotherapy Co-operative Group. Eur J Cancer 34:1902–1909PubMedCrossRefGoogle Scholar
- 43.Duffau H, Capelle L, Denvil D, Sichez N, Gatignol P, Taillandier L, Lopes M, Mitchell MC et al (2003) Usefulness of intraoperative electrical subcortical mapping during surgery for low-grade gliomas located within eloquent brain regions: functional results in a consecutive series of 103 patients. J Neurosurg 98:764–778PubMedCrossRefGoogle Scholar
- 44.Medical Research Council (1981) Aids to the examination of the peripheral nervous system. Memorandum no. 45. Her Majesty’s Stationery Office, LondonGoogle Scholar