Journal of Neuro-Oncology

, 105:119 | Cite as

Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG

  • Ute Bartels
  • Cynthia Hawkins
  • Gilbert Vézina
  • Larry Kun
  • Mark Souweidane
  • Eric Bouffet
Meeting Proceedings


Diffuse intrinsic pontine glioma (DIPG) nearly exclusively affects children. The prognosis of DIPGs has remained grim despite more than three decades of clinical research and numerous clinical trials. More than 90% of the children with DIPG will succumb within 2 years of diagnosis. The tumor’s incidence is still undefined, but data suggest 100–150 affected children annually in the US. The single proven effective treatment modality in DIPG remains radiation therapy. For the majority of patients however this treatment is only of transient effectiveness. Recent breakthroughs in the understanding of the molecular biology of DIPG have raised new hope and opened new avenues for therapeutic options. The advancement of basic and translational research and cooperation was the objective of the Toronto Think Tank, as new approaches are urgently needed.


Diffuse intrinsic pontine glioma DIPG Think tank 


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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Ute Bartels
    • 1
  • Cynthia Hawkins
    • 2
  • Gilbert Vézina
    • 3
  • Larry Kun
    • 4
  • Mark Souweidane
    • 5
    • 6
  • Eric Bouffet
    • 1
  1. 1.Division of Haematology/OncologyThe Hospital for Sick Children, University of TorontoTorontoCanada
  2. 2.Division of PathologyThe Hospital for Sick Children, University of TorontoTorontoCanada
  3. 3.Department of Radiology and Diagnostic ImagingChildren’s National Medical CenterWashingtonUSA
  4. 4.Department of Radiological SciencesSt. Jude Children’s Research HospitalMemphisUSA
  5. 5.Department of Neurological SurgeryWeill Medical College of Cornell University and Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  6. 6.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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