Journal of Neuro-Oncology

, Volume 105, Issue 3, pp 451–466 | Cite as

The roles of viruses in brain tumor initiation and oncomodulation

  • Alexander Kofman
  • Lucasz Marcinkiewicz
  • Evan Dupart
  • Anton Lyshchev
  • Boris Martynov
  • Anatolii Ryndin
  • Elena Kotelevskaya
  • Jay Brown
  • David Schiff
  • Roger Abounader
Topic Review


While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.


Gliomas Brain tumors Viruses Herpesviruses Retroviruses Oncomodulation Progenitors Stem cells 



We thank Chris Letson for reading and correcting the manuscript. Supported by NIH RO1 NS045209 (R. Abounader) and NIH R01 CA134843 (R. Abounader).


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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Alexander Kofman
    • 1
  • Lucasz Marcinkiewicz
    • 1
  • Evan Dupart
    • 1
  • Anton Lyshchev
    • 3
  • Boris Martynov
    • 4
  • Anatolii Ryndin
    • 5
  • Elena Kotelevskaya
    • 3
  • Jay Brown
    • 1
  • David Schiff
    • 2
  • Roger Abounader
    • 1
    • 2
  1. 1.Department of MicrobiologyUniversity of VirginiaCharlottesvilleUSA
  2. 2.Department of Cancer CenterUniversity of VirginiaCharlottesvilleUSA
  3. 3.St. Petersburg State Department of HealthLaboratory of Molecular Genetics, Hospital #31St. PetersburgRussia
  4. 4.S.M.Kirov Medical AcademySt. PetersburgRussia
  5. 5.Clinical Diagnostic CenterSt. PetersburgRussia

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