Journal of Neuro-Oncology

, Volume 105, Issue 2, pp 127–134 | Cite as

Primary intraocular lymphoma: a review

  • Gregory S. Vosganian
  • Saskia Boisot
  • Kathrin I. Hartmann
  • William R. Freeman
  • Robert W. Sharpe
  • Prabhakar Tripuraneni
  • Alan Saven
Topic Review


Primary intraocular lymphoma (PIOL) is a rare, non-Hodgkin lymphoma considered to be a subtype of primary central nervous system lymphoma. We describe a 65-year-old woman who presented to the Hematology/Oncology Clinic at Scripps Clinic, La Jolla, California, who was diagnosed with bilateral PIOL without systemic disease. She enjoyed a 16-month remission but ultimately recurred in the brain. We reviewed the literature and present a discussion of the diagnostic criteria for PIOL and current strategies for treating PIOL in immunocompetent patients.


Intraocular lymphoma Non-Hodgkin lymphoma Central nervous system lymphoma Therapies Autologous transplantation Chemotherapy Chemo-immunotherapy 


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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Gregory S. Vosganian
    • 1
  • Saskia Boisot
    • 2
  • Kathrin I. Hartmann
    • 3
  • William R. Freeman
    • 3
  • Robert W. Sharpe
    • 2
  • Prabhakar Tripuraneni
    • 4
  • Alan Saven
    • 1
  1. 1.Division of Hematology/OncologyScripps ClinicLa JollaUSA
  2. 2.Division of HematopathologyScripps ClinicLa JollaUSA
  3. 3.The Division of Ophthalmology, Shiley Eye Center/Jacobs Retina CenterUniversity of California-San DiegoLa JollaUSA
  4. 4.Division of Radiation/OncologyScripps Clinic and Green HospitalLa JollaUSA

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