Journal of Neuro-Oncology

, 105:317 | Cite as

Sarcoma arising as a distinct nodule within glioblastoma: a morphological and molecular perspective on gliosarcoma

  • Cynthia Jimenez
  • Martin Powers
  • Andrew T. Parsa
  • Christine Glastonbury
  • Jill M. Hagenkord
  • Tarik Tihan
Clinical Study – Patient Study

Abstract

Gliosarcoma is a variant of glioblastoma and is characterized by distinct glial and sarcomatous components. Typically, there is no macroscopic boundary between the components and special stains are often required to distinguish the glial and sarcomatous elements. Some studies suggest similar genetic alterations in both components pointing to a common origin. We present an extreme case of gliosarcoma arising as a discrete fibrous nodule adjacent to a typical glioblastoma. A 65 year-old woman presented with progressive weakness, seizures and right-sided hemiparesis. CT scan demonstrated an irregular enhancing left frontal lobe mass and an adjacent discrete nodule with different imaging characteristics. The unique nature of this macroscopically biphasic neoplasm allowed us to compare the molecular characteristics of glial and sarcomatous elements which were strikingly similar except for small losses and gains in Chr 3. Studies are under way to determine the significance of chromosome 3 alterations in gliosarcomas.

Keywords

Gliosarcoma Sarcomatous glioma Genotype SNP 

Notes

Acknowledgment

We are deeply grateful to Dr. Shera Kash, PhD from the Molecular Pathology and Clinical Genomics Division of the Department of Pathology and Creighton Medical Labs for her expert contribution and the analysis of the 250 K Affymetrix NspI single nucleotide polymorphism (SNP) arrays.

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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Cynthia Jimenez
    • 1
  • Martin Powers
    • 1
  • Andrew T. Parsa
    • 3
  • Christine Glastonbury
    • 2
  • Jill M. Hagenkord
    • 4
  • Tarik Tihan
    • 1
  1. 1.Department of Pathology, Neuropathology UnitUniversity of California at San FranciscoSan FranciscoUSA
  2. 2.Department of RadiologyUniversity of California at San FranciscoSan FranciscoUSA
  3. 3.Department of Neurological SurgeryUniversity of California San FranciscoSan FranciscoUSA
  4. 4.Department of Pathology, iKaryos DiagnosticsCreighton University Medical LaboratoriesOmahaUSA

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