Journal of Neuro-Oncology

, Volume 104, Issue 2, pp 589–594 | Cite as

Is the incidence of brain tumors really increasing? A population-based analysis from a cancer registry

  • Adele Caldarella
  • Emanuele Crocetti
  • Eugenio Paci
Clinical Study – Patient Study

Abstract

Recently, an increasing incidence of brain tumors has been reported from multiple studies. Brain tumors diagnosed in the period 1985–2005 were identified through the Tuscan Cancer Registry, a population-based registry active since 1985 in the area of Florence and Prato. Age-standardized incidence rates and average annual percent change (APC) was calculated for the entire period from 1985 to 2005 for sex and behavior. A total of 4,417 brain tumors was registered, 1,900 (43%) in male and 2,517 (57%) in female patients. Malignant and benign tumor incidence rates were 8.3 and 4.1, respectively, among males and 6.4 and 7.2, respectively, among females. The age-adjusted annual incidence rate of all brain tumors was 13.9, with a statistically significant increasing rate throughout the period (APC: +3.2, CI 2.2–4.2). The annual incidence rate remained stable for malignant brain tumors but increased significantly for benign brain tumors (APC: +6.2, CI 4.5–7.9). In our population-based study, the incidence of brain tumors increased from 1985 to 2005 overall and for benign tumors, but not for malignant tumors. Part of the temporal variations may be attributed to improvement in diagnostic imaging techniques and, particularly for benign tumors, in changes in registration practice.

Keywords

Brain tumor Tumor incidence Cancer registry Population-based analysis 

References

  1. 1.
    Arora RS, Alston RD, Eden TOB et al (2010) Are reported increases in incidence of primary CNS tumors real? An analysis of longitudinal trends in England, 1979–2003. Eur J Cancer 46:1607–1616PubMedCrossRefGoogle Scholar
  2. 2.
    Porter KR, McCarthy BJ, Freels S, Kim Y, Davis FG (2010) Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology. Neuro Oncol 12:520–527PubMedCrossRefGoogle Scholar
  3. 3.
    Wohrer A, Waldhor T, Heinzl H et al (2009) The Austrian Brian Tumor Registry: a cooperative way to establish a population-based brain tumor registry. J Neurooncol 95:401–411PubMedCrossRefGoogle Scholar
  4. 4.
    Bray F, Engholm G, Hakulinen T, Gislum M, Tryggvadòttir L, Storm HH, Klint A (2010) Trends in survival of patients diagnosed with cancers of the brain and nervous system, thyroid, eye, bone, and soft tissues in the Nordic countries 1964–2003 followed up until the end of 2006. Acta Oncol 49:673–693PubMedCrossRefGoogle Scholar
  5. 5.
    Wrensch M, Minn Y, Chew T, Bondy M, Berger MS (2002) Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro-oncology 4:278–299PubMedGoogle Scholar
  6. 6.
    Greig NH, Ries LG, Yancik R, Rappaport SI (1990) Increasing annual incidence of primary malignant brain tumors in the elderly. J Natl Cancer Inst 82:1621–1624PubMedCrossRefGoogle Scholar
  7. 7.
    Hoffman S, Propp JM, McCarthy BJ (2006) Temporal trends in incidence of primary brain tumors in the United States, 1985–1999. Neuro-oncology 8:27–37PubMedCrossRefGoogle Scholar
  8. 8.
    Kleihues P, Cavenee WK (2000) WHO classification of tumors. Pathology and genetics of tumors of the nervous system. IARC Press, LyonGoogle Scholar
  9. 9.
    CBTRUS Statistical Report 2009–2010 (2009) Primary brain and central nervous system tumors diagnosed in Eighteen States in 2002–2006. Central Brain Tumor Regsitry of the United States, Hinsdale www.cbtrus.org at http://7cbtrus.org/2009EighteenStates/CBTRUSReport-2002–2006-new.pdf
  10. 10.
    CBTRUS Statistical Report (2010) Primary Brain and Central Nervous System Tumors diagnosed in the United States in 2004–2006. Central Brain Tumor Regsitry of the United States, Hinsdale www.cbtrus.org at http://7cbtrus.org/2010-NCPR-SEER/CBTRUS-WEBREPORT-Final-3-2-10.pdf
  11. 11.
    Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG, The collaborating registries of the Central Brain Tumor Registry of the United States (1999) Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990–1994. Neuro Oncology 1:14–25PubMedGoogle Scholar
  12. 12.
    Arora RS, Alston RD, Edwen TOB, Estlin EJ, Moran A, Birch JM (2009) Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England. Neuro Oncology 11:403–413PubMedCrossRefGoogle Scholar
  13. 13.
    Makino K, Nakamura H, Yano S, Kuratsu JI (2010) Population based epidemiological study of primary intracranial tumors in childhood. Childs Nerv Syst 27:1029–1034CrossRefGoogle Scholar
  14. 14.
    AIRTUM working group (2007) Italian cancer figures, report 2007: survival. Epid Prev 31(1(supp1)):88–89Google Scholar
  15. 15.
    Larjavaara S, Haapasalo H, Sankila R, Helèn P, Auvinen A (2008) Is the incidence of meningiomas underestimated? A regional survey. Br J Cancer 99:182–184PubMedCrossRefGoogle Scholar
  16. 16.
    Kieran MW, Walker D, Frappaz D, Prados M (2010) Brain tumors: from childhood through adolescence into adulthood. J Clin Oncol. DOI  10.1200/JCO.2010.28.3481
  17. 17.
    Lonn S, Klaeboe L, Hall P, Mathiesen T, Auvinen A, Christensen H, Johansen C, Salminen T, Tynes T, Feychting M (2004) Incidence trends of adult primary intracerebral tumors in four Nordic countries. Int J Cancer 108:450–455PubMedCrossRefGoogle Scholar
  18. 18.
    Deltour I, Johansen C, Auvinen A et al (2009) Time trends in brain tumor incidence rates in Denmark, Finland, Norway, and Sweden, 1974–2003. J Natl Cancer Inst 101:1721–1724PubMedCrossRefGoogle Scholar
  19. 19.
    Dorè JF, Boniol M, Lamberton M (2010) Re: time trend in brain tumor incidence rates in Denmark, Finland, Norway, and Sweden, 1974–2003. J Natl Cancer Inst 102:740–741CrossRefGoogle Scholar
  20. 20.
  21. 21.
    The INTERPHONE Study Group (2010) Brain tumor risk in relation to mobile telephone use: results of the INTERPHONE international case-control study. Int J Epid 39:675–694CrossRefGoogle Scholar
  22. 22.
    Saracci R, Samet J (2010) Commentary: call me on my mobile phone.or better not?-a look at the INTERPHONE study results. Int J Epid 39:695–698CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Adele Caldarella
    • 1
  • Emanuele Crocetti
    • 1
  • Eugenio Paci
    • 1
  1. 1.Clinical and Descriptive Epidemiology UnitInstitute for Study and Cancer Prevention (ISPO)FlorenceItaly

Personalised recommendations