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Journal of Neuro-Oncology

, Volume 103, Issue 3, pp 657–662 | Cite as

The role of chemotherapy in pediatric clival chordomas

  • Girish DhallEmail author
  • Mercedes Traverso
  • Jonathan L. Finlay
  • Lisa Shane
  • Ignacio Gonzalez-Gomez
  • Rima Jubran
Clinical Study – Patient Study

Abstract

The purpose of this retrospective study was to review the role of chemotherapy in the treatment, management and outcome of children diagnosed with clival chordomas. The medical records of six pediatric chordoma patients diagnosed at Childrens Hospital Los Angeles between 1995 and 2005 were reviewed. Of the six patients reviewed, all underwent an initial surgical resection. Following resection, three received a combination of chemotherapy and radiation therapy, two received chemotherapy alone and one patient refused both forms of therapy; this patient expired of progressive tumor. One patient developed acute monoblastic leukemia (M5a subtype) and died of intracranial hemorrhage during induction chemotherapy, 39 months after initial diagnosis. MRI of brain and spine showed disease progression shortly before his death. Two patients who received chemotherapy only after surgery, one patient who received chemotherapy at relapse following irradiation and one patient who received irradiation followed by chemotherapy are alive with stable radiographic abnormalities at a median follow-up of 9 years from diagnosis (range: 6–13 years). Chemotherapeutic agents included ifosfamide and etoposide in all four surviving patients. Chemotherapy with ifosfamide and etoposide may have a role in the treatment of pediatric clival chordomas when used alone or in combination with irradiation.

Keywords

Chemotherapy Pediatric Chordomas 

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Girish Dhall
    • 1
    • 2
    Email author
  • Mercedes Traverso
    • 1
  • Jonathan L. Finlay
    • 1
  • Lisa Shane
    • 1
  • Ignacio Gonzalez-Gomez
    • 1
  • Rima Jubran
    • 1
  1. 1.Neural Tumors Program, The Division of Pediatric Hematology-Oncology and Department of Pathology at Childrens Hospital Los AngelesLos AngelesUSA
  2. 2.Neural Tumors Program, Childrens Hospital Los Angeles, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA

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