Journal of Neuro-Oncology

, Volume 103, Issue 3, pp 759–764

Medulloblastoma with melanotic differentiation: case report and review of the literature

  • Christine L. Phillips
  • Lili Miles
  • Blaise V. Jones
  • Mary Sutton
  • Kerry Crone
  • Maryam Fouladi
Case Report

DOI: 10.1007/s11060-010-0436-x

Cite this article as:
Phillips, C.L., Miles, L., Jones, B.V. et al. J Neurooncol (2011) 103: 759. doi:10.1007/s11060-010-0436-x

Abstract

Medulloblastoma with melanotic differentiation, a rare variant of medulloblastoma, often carries a poor prognosis. We present such a case of a 4 year male with this rare, aggressive tumor. Additionally, we have reviewed the literature and report on the features important in the pathologic and radiologic diagnosis in this type of tumor, as well as review clinical outcomes. This subtype of medulloblastoma occurs more frequently in males, at a younger median age than the other subtypes of medulloblastoma. The prognosis is generally very poor. However, it is important to note, that a subset of patients with M0 disease who can achieve a gross total resection followed by radiation and platinum based chemotherapy can become long term survivors of this aggressive subtype of medulloblastoma.

Keywords

Medulloblastoma with melanotic differentiation Melanotic medulloblastoma Melanocytic medulloblastoma Pediatric medulloblastoma 

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Christine L. Phillips
    • 1
  • Lili Miles
    • 2
  • Blaise V. Jones
    • 3
  • Mary Sutton
    • 4
  • Kerry Crone
    • 5
  • Maryam Fouladi
    • 1
  1. 1.Division of Hematology/OncologyCincinnati Children’s Hospital Medical Center, University of CincinnatiCincinnatiUSA
  2. 2.Division of Pathology and Laboratory MedicineCincinnati Children’s Hospital Medical Center, University of CincinnatiCincinnatiUSA
  3. 3.Department of RadiologyCincinnati Children’s Hospital Medical Center, University of CincinnatiCincinnatiUSA
  4. 4.Division of NeurologyCincinnati Children’s Hospital Medical Center, University of CincinnatiCincinnatiUSA
  5. 5.Division of NeurosurgeryCincinnati Children’s Hospital Medical Center, University of CincinnatiCincinnatiUSA

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