Journal of Neuro-Oncology

, Volume 101, Issue 2, pp 311–318

Malignant ganglioglioma: case report and review of literature

  • Ryan DeMarchi
  • Suzy Abu-Abed
  • David Munoz
  • R. Loch Macdonald
Case Report

DOI: 10.1007/s11060-010-0248-z

Cite this article as:
DeMarchi, R., Abu-Abed, S., Munoz, D. et al. J Neurooncol (2011) 101: 311. doi:10.1007/s11060-010-0248-z

Abstract

We report a case of de novo malignant ganglioglioma. A 61-year-old male presented with a 12-day history of headaches and general malaise. Pre-operative magnetic resonance imaging revealed an irregular enhancing mass in the left temporal lobe with associated dural enhancement and subacute subdural hematoma. The findings at surgery were of a vascular tumor intimately involving the surrounding white matter, with central necrosis. Histological and immunohistochemical studies showed an anaplastic ganglioglioma with World Health Organization grade IV characteristics. Gangliogliomas of the central nervous system are rare and are typified by a pediatric predilection and indolent behavior. A review of the de novo anaplastic and malignant gangliogliomas is presented.

Keywords

Ganglioglioma Dural enhancement Neuroepithelial tumor Mixed glioneuronal tumor 

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Ryan DeMarchi
    • 1
    • 3
  • Suzy Abu-Abed
    • 2
  • David Munoz
    • 2
  • R. Loch Macdonald
    • 1
    • 3
  1. 1.Division of NeurosurgerySt. Michael’s Hospital, Keenan Research Centre, the Li Ka Shing Knowledge InstituteTorontoCanada
  2. 2.Department of PathologySt. Michael’s Hospital, Keenan Research Centre, the Li Ka Shing Knowledge InstituteTorontoCanada
  3. 3.Department of SurgeryUniversity of TorontoTorontoCanada

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