Journal of Neuro-Oncology

, Volume 101, Issue 2, pp 301–306 | Cite as

Pineal parenchymal tumor of intermediate differentiation with papillary features: a continuum of primary pineal tumors?

  • Jessica N. Cohan
  • Jennifer A. Moliterno
  • Christina L. Mok
  • Ehud Lavi
  • John A. BoockvarEmail author
Case Report


Pineal parenchymal tumors comprise a rare group of primary neoplasms of the pineal gland. We describe a case involving a 29-year-old woman who presented with signs and symptoms of hydrocephalus secondary to a pineal region tumor obstructing the third ventricle. Surgical resection was performed and pathological analysis revealed a novel diagnosis consistent with a pineal parenchymal tumor of intermediate differentiation (PPTID) with transition to a papillary tumor of the pineal region (PTPR). To our knowledge, this particular pineal region tumor pathology has not yet been reported in the literature and highlights the continuum with which primary pineal tumors exist. We provide a review of the existing literature on pineal region tumors, specifically PTPR and PPTID, and offer insight into the management of these rare neoplasms.


Pineal parenchymal tumor Obstructive hydrocephalus Papillary tumor of the pineal region Pineal parenchymal tumor of intermediate differentiation 



Pineal parenchymal tumor of intermediate differentiation


Papillary tumor of the pineal region


Pineal parenchymal tumor


Central nervous system


World Health Organization






Magnetic resonance imaging


Endoscopic third ventriculostomy


Placental alkaline phosphatase




Alpha fetoprotein


Glial fibrillary acidic protein




Human chorionic gonadotropin


Epithelial membrane antigen


Neuron specific enolase


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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Jessica N. Cohan
    • 1
  • Jennifer A. Moliterno
    • 2
  • Christina L. Mok
    • 1
  • Ehud Lavi
    • 3
  • John A. Boockvar
    • 1
    Email author
  1. 1.Department of Neurological Surgery, Weill Cornell Brain Tumor CenterWeill Medical College of Cornell University, New York Presbyterian HospitalNew YorkUSA
  2. 2.Department of NeurosurgeryYale University School of Medicine, Yale-New Haven HospitalNew HavenUSA
  3. 3.Department of PathologyWeill Cornell Medical College of Cornell University, New York Presbyterian HospitalNew YorkUSA

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