Journal of Neuro-Oncology

, Volume 100, Issue 3, pp 427–437 | Cite as

Computer-based assessment of cognitive functions in brain tumor patients

  • Klaus Fliessbach
  • Sabine Rogowski
  • Christian Hoppe
  • Michael Sabel
  • Mathias Goeppert
  • Christoph Helmstaedter
  • Pasquale Calabrese
  • Gabriele Schackert
  • Joerg-Christian Tonn
  • Matthias Simon
  • Uwe Schlegel
Clinical Study – Patient Study


NeuroCogFX is a short yet comprehensive computer-based neuropsychological battery of tests developed to investigate neurological patients for cognitive dysfunction after potentially neurotoxic therapy. NeuroCogFX had been standardized in a group of 242 healthy controls (Fliessbach et al., Fortschr Neurol Psychiatr 74:643–650, 2006). The present study was conducted to assess the practicability, reliability, and validity of NeuroCogFX in brain tumor patients without active disease after tumor-directed therapy. To evaluate its validity, neuropsychological testing with NeuroCogFX was completed parallel to a battery of established neuropsychological tests in 54 patients with different types of brain tumors and without active disease for at least 6 months. Retest reliability was assessed in a different sample of 49 patients with gliomas. Results showed good practicability with a median test duration of 28 min (range 16–51 min). Most subtests showed medium-sized retest reliability in healthy controls and tumor patients, with the exception of the 2-back test and reaction time measures in tumor patients. Convergent validity was confirmed for the domains psychomotor speed, verbal memory, and verbal short-term memory. NeuroCogFX enables serial scientific neuropsychological assessment of brain tumor patients. It can be carried out within a short period of time by non-academic personnel and is therefore applicable to large cohorts, e.g., within clinical trials.


Neuropsychological test Neurotoxicity Computerized (computer-based, computer-assisted) testing Follow-up examination 


Conflict of Interest Statement

With kind permission of the University of Bonn Medical Centre NeuroCogFX is marketed by three of the authors (C. Hoppe, K. Fliessbach, C. Helmstaedter).


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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Klaus Fliessbach
    • 1
  • Sabine Rogowski
    • 2
  • Christian Hoppe
    • 1
  • Michael Sabel
    • 3
  • Mathias Goeppert
    • 3
  • Christoph Helmstaedter
    • 1
  • Pasquale Calabrese
    • 4
  • Gabriele Schackert
    • 5
  • Joerg-Christian Tonn
    • 6
  • Matthias Simon
    • 7
  • Uwe Schlegel
    • 2
  1. 1.Department of EpileptologyUniversity of BonnBonnGermany
  2. 2.Knappschaftskrankenhaus Bochum-Langendreer, Department of NeurologyRuhr University BochumBochumGermany
  3. 3.Department of NeurosurgeryUniversity of DüsseldorfDüsseldorfGermany
  4. 4.Department of PsychologyUniversity of BaselBaselSwitzerland
  5. 5.Department of NeurosurgeryUniversity of DresdenDresdenGermany
  6. 6.Department of NeurosurgeryUniversity of MunichMunichGermany
  7. 7.Department of NeurosurgeryUniversity of BonnBonnGermany

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