Journal of Neuro-Oncology

, Volume 99, Issue 2, pp 287–288 | Cite as

Multiple paraneoplastic diseases occurring in the same patient after thymomectomy

  • C. BrianiEmail author
  • A. Cagnin
  • S. Blandamura
  • G. Altavilla
Case Report


Thymoma-associated paraneoplastic diseases include myasthenia gravis (MG), neuromyotonia (NMT), Morvan’s syndrome, and several non-neurological paraneoplastic manifestations, including glomerulonephritis. Paraneoplastic syndromes often precede the occurrence of thymoma, but cases occurring after thymomectomy, which sometimes herald the recurrence of thymoma, have also been described. We report on a patient who developed MG after thymomectomy for a malignant thymoma. After MG remission, NMT and Morvan’s syndrome occurred, which heralded a mediastinic recurrence, as demonstrated only by autopsy findings.


Myasthenia gravis Neuromyotonia Paraneoplastic diseases Thymoma Morvan’s syndrome 


  1. 1.
    Evoli A, Minicuci GM, Vitaliani R et al (2007) Paraneoplastic diseases associated with thymoma. J Neurol 254:756–762CrossRefPubMedGoogle Scholar
  2. 2.
    Terauchi K, Shimada J, Kato D et al (2005) Lung metastasis of thymoma manifesting as myasthenia gravis 12 years after thymomectomy: report of a case. Surg Today 35:309–312CrossRefPubMedGoogle Scholar
  3. 3.
    Kondo K, Monden Y (2005) Myasthenia gravis appearing after thymectomy for thymoma. Eur J Cardiothorac Surg 28:22–25CrossRefPubMedGoogle Scholar
  4. 4.
    Cottrell DA, Blackmore KJ, Fawcett PR et al (2004) Sub-acute presentation of Morvan’s syndrome after thymectomy. J Neurol Neurosurg Psychiatry 75:1504–1505CrossRefPubMedGoogle Scholar
  5. 5.
    Morvan A (1890) De le chorée fibrillaire. Gazette Hebdomadaire Mèdicine Chirurgie 27:173–200Google Scholar
  6. 6.
    Liguori R, Vincent A, Clover L, Avoni P, Plazzi G, Cortelli P, Baruzzi A, Carey T, Gambetti P, Lugaresi E (2001) Morvan’s syndrome: peripheral and central nervous system involvement with antibodies to voltage-gated potassium channels. Brain 124:2417–2426CrossRefPubMedGoogle Scholar
  7. 7.
    Ströbel P, Helmreich M, Menioudakis G et al (2002) Paraneoplastic myasthenia gravis correlates with generation of mature naïve CD4(+) T cells in thymomas. Blood 100:159–166CrossRefPubMedGoogle Scholar
  8. 8.
    Buckley C, Douek D, Newsom-Davis J, Vincent A, Willcox N (2001) Mature, long-lived CD4+ and CD8+ T cells are generated by the thymoma in myasthenia gravis. Ann Neurol 50:64–72CrossRefPubMedGoogle Scholar
  9. 9.
    Fattorossi A, Battaglia A, Buzzonetti A et al (2008) Thymopoiesis, regulatory T cells, and TCRVbeta expression in thymoma with and without myasthenia gravis, and modulatory effects of steroid therapy. J Clin Immunol 28:194–206CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • C. Briani
    • 1
    Email author
  • A. Cagnin
    • 1
  • S. Blandamura
    • 2
  • G. Altavilla
    • 2
  1. 1.Departments of NeurosciencesUniversity of PadovaPadovaItaly
  2. 2.Medical Diagnostic Sciences and Special TherapiesUniversity of PaduaPadovaItaly

Personalised recommendations