Journal of Neuro-Oncology

, Volume 99, Issue 2, pp 277–281

Primary central nervous system Burkitt lymphoma as concomitant lesions in the third and the left ventricles: a case study and literature review

Case Report


This study reports the case of a 75-year-old woman with intermittent speech disturbance, headache, and general malaise. Brain magnetic resonance imaging showed a double lesion located in the third ventricle and temporal horn of the lateral ventricle. We completely removed the lesion in the third ventricle, adhering to the septum pellucidum. The histopathological diagnosis was Burkitt lymphoma, which was confirmed to be primary in postoperative investigation. To our knowledge, this is the first case of primary Burkitt lymphoma involving cerebral ventricles. Finally, we reviewed the characteristics of primary central nervous system Burkitt lymphoma.


Primary central nervous system lymphoma Burkitt lymphoma Multifocal intraventricular tumors Third ventricle 


  1. 1.
    Sivapatham T, Newton H, Bourekas E, Slone H (2008) Primary CNS lymphoma. In: Newton H, Jolesz F (eds) Handbook of neuro-oncology neuroimage. Elsevier, New York, pp 369–371Google Scholar
  2. 2.
    Valsamis MP, Levine PH, Rapin I et al (1976) Primary intracranial Burkitt’s lymphoma in an infant. Cancer 37(3):1500–1507CrossRefPubMedGoogle Scholar
  3. 3.
    Jellinger K (1979) Maligne Lymphome des Zentralnervensystems. In: Hocker P, Stacher A (eds) Lymphknotentumoren. Urban & Schwarzenberg, Miinchen Wien, New York, pp 240–247Google Scholar
  4. 4.
    Giromini D, Peiffer J, Tzonos T (1981) Occurrence of a primary Burkitt-type lymphoma of the central nervous system in an astrocytoma patient: a case report. Acta Neuropathol 54(2):165–167CrossRefPubMedGoogle Scholar
  5. 5.
    Kobayashi H, Sano T, Ii K et al (1984) Primary Burkitt-type lymphoma of the central nervous system. Acta Neuropathol 64(1):12–14CrossRefPubMedGoogle Scholar
  6. 6.
    Mizugami T, Mikata A, Hajikano H et al (1987) Primary spinal epidural Burkitt’s lymphoma. Surg Neurol 28(2):158–162CrossRefPubMedGoogle Scholar
  7. 7.
    Tekkök IH, Tahta K, Erbengi A et al (1991) Primary intracranial extradural Burkitt-type lymphoma: a unique presentation with unilateral loss of vision in a child. Childs Nerv Syst 7(3):172–174CrossRefPubMedGoogle Scholar
  8. 8.
    Toren A, Mandel M, Shahar E et al (1994) Primary central nervous system Burkitt’s lymphoma presenting as Guillain–Barré syndrome. Med Pediatr Oncol 23(4):372–375CrossRefPubMedGoogle Scholar
  9. 9.
    Späth-Schwalbe E, Genvresse I, Stein H et al (1999) Primary cerebral highly-malignant B-cell lymphoma of the Burkitt type. Dtsch Med Wochenschr 124(15):451–455CrossRefPubMedGoogle Scholar
  10. 10.
    Wilkening A, Brack M, Brandis A et al (2001) Unusual presentation of a primary spinal Burkitt’s lymphoma. J Neurol Neurosurg Psychiatry 70(6):794–797CrossRefPubMedGoogle Scholar
  11. 11.
    Monabati A, Rakei SM, Kumar P et al (2002) Primary Burkitt lymphoma of the brain in an immunocompetent patient. J Neurosurg 96(6):1127–1129CrossRefPubMedGoogle Scholar
  12. 12.
    Shehu BB (2003) Primary central nervous system Burkitt’s lymphoma presenting with proptosis. Ann Trop Paediatr 23(4):319–320CrossRefPubMedGoogle Scholar
  13. 13.
    Daley MF, Partington MD, Kadan-Lottick N et al (2003) Primary epidural burkitt lymphoma in a child: case presentation and literature review. Pediatr Hematol Oncol 20(4):333–338PubMedGoogle Scholar
  14. 14.
    Gobbato PL et al (2006) Primary meningeal Burkitt-type lymphoma presenting as the first clinical manifestation of acquired immunodeficiency syndrome. Arq Neuropsiquiatr 64(2B):511–515PubMedGoogle Scholar
  15. 15.
    Abel TW, Thompson MA, Kim J et al (2006) Primary central nervous system Burkitt lymphoma: report of a case confirmed with identification of t(8;14) by fish. Brain Pathol 16(Suppl 1):96–97Google Scholar
  16. 16.
    Kozáková D, Macháleková K, Brtko P et al (2008) Primary B-cell pituitary lymphoma of the Burkitt type: case report of the rare clinic entity with typical clinical presentation. Cas Lek Cesk 147(11):569–573PubMedGoogle Scholar
  17. 17.
    Swerdlow S, Campo E, Harris NL et al (2008) WHO classification of tumors of hematopoietic and lymphoid tissues. IARC, LyonGoogle Scholar
  18. 18.
    Hummel M, Bentink S, Berger H et al (2006) A biological definition of Burkitt’s lymphoma from transcriptional and genomic profiling. N Engl J Med 354:2419–2430CrossRefPubMedGoogle Scholar
  19. 19.
    Küker W, Nägele T, Korfel A et al (2005) Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. J Neurooncol 72(2):169–177CrossRefPubMedGoogle Scholar
  20. 20.
    Haldorsen IS, Kråkenes J, Krossnes BK et al (2009) CT and MR imaging features of primary central nervous system lymphoma in Norway, 1989–2003. AJNR Am J Neuroradiol 30(4):744–751CrossRefPubMedGoogle Scholar
  21. 21.
    Coulon A, Lafitte F, Hoang-Xuan K et al (2002) Radiographic findings in 37 cases of primary CNS lymphoma in immunocompetent patients. Eur Radiol 12(2):329–340CrossRefPubMedGoogle Scholar
  22. 22.
    Di Rocco F, Caldarelli M, Sabatino G et al (2004) Lateral ventricle choroid plexus papilloma extending into the third ventricle. Pediatr Neurosurg 40(6):314–316CrossRefPubMedGoogle Scholar
  23. 23.
    Maurice-Williams RS, Wadley JP (1998) Paired colloid cysts of the third and lateral ventricles. Br J Neurosurg 12(1):47–50CrossRefPubMedGoogle Scholar
  24. 24.
    Chamberlain MC, Nolan C, Abrey LE (2005) Leukemic and lymphomatous meningitis: incidence, prognosis and treatment. J Neurooncol 75(1):71–83CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  1. 1.Department of NeurosurgeryZhongshan Hospital, Fudan UniversityShanghaiChina
  2. 2.Department of PathologyZhongshan Hospital, Fudan UniversityShanghaiChina

Personalised recommendations