Journal of Neuro-Oncology

, Volume 99, Issue 1, pp 115–122 | Cite as

Gamma Knife stereotactic radiosurgery for intracranial hemangiopericytomas

  • Jin Wook Kim
  • Dong Gyu KimEmail author
  • Hyun-Tai Chung
  • Sun Ha Paek
  • Yong Hwy Kim
  • Jung Ho Han
  • Chul-Kee Park
  • Chae-Yong Kim
  • Hee-Won Jung
Clinical Study - Patient Study


The purpose of this study is to determine the efficacy of Gamma Knife stereotactic radiosurgery (GK SRS) for intracranial hemangiopericytomas, and to investigate the optimal dose for successful tumor control without adverse effects. We evaluated 17 hemangiopericytomas of nine patients treated with GK SRS between 1999 and 2008. The mean tumor volume was 2.2 cm3 (range 0.2–9.9 cm3), and the mean and median marginal doses were 18.1 and 20 Gy (range 11–22 Gy), respectively, at the 50% isodose line. Mean clinical and radiological follow-up periods were 49 and 34 months, respectively. Successful tumor control was achieved in 14 of 17 lesions (82.4%) at time of last follow-up after GK SRS. Actuarial local tumor control rates at 1, 2, and 5 years after GK SRS were 100%, 84.6%, and 67.7%, respectively. No adverse effects, such as radiation necrosis or marked peritumoral edema, were observed in any patient. Marginal dose (≥17 Gy) was the only statistically significant factor for local tumor control on univariate analysis. Extended analysis using lesion data available from previous studies revealed that higher marginal dose (≥17 Gy) was also significant (P = 0.028). GK SRS provides an effective and safe adjuvant management option for patients with recurrent or residual hemangiopericytomas. Our results suggest that doses higher than previously used (around 15 Gy) are desirable to achieve better local tumor control of hemangiopericytomas. Close radiological follow-up is also necessary for early detection of small recurrent lesions.


Hemangiopericytoma Tumor control Radiosurgery Gamma Knife Radiation dose 





Gamma Knife stereotactic radiosurgery


Radiation therapy


World Health Organization


Magnetic resonance imaging



This work was supported by the Nuclear Research and Development Program of the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MEST) (Grant: M800-20090068).


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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Jin Wook Kim
    • 1
  • Dong Gyu Kim
    • 1
    • 3
    Email author
  • Hyun-Tai Chung
    • 1
  • Sun Ha Paek
    • 1
    • 2
  • Yong Hwy Kim
    • 1
  • Jung Ho Han
    • 1
  • Chul-Kee Park
    • 1
  • Chae-Yong Kim
    • 1
  • Hee-Won Jung
    • 1
  1. 1.Department of NeurosurgerySeoul National University College of MedicineSeoulKorea
  2. 2.Cancer Research Institute, Ischemic/Hypoxic Disease InstituteSeoul National University College of MedicineSeoulKorea
  3. 3.Department of NeurosurgerySeoul National University HospitalSeoulKorea

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