Journal of Neuro-Oncology

, Volume 95, Issue 3, pp 301–305

Neurological outcome of long-term glioblastoma survivors

  • Andreas F. Hottinger
  • Hannah Yoon
  • Lisa M. DeAngelis
  • Lauren E. Abrey
Topic Review

DOI: 10.1007/s11060-009-9946-9

Cite this article as:
Hottinger, A.F., Yoon, H., DeAngelis, L.M. et al. J Neurooncol (2009) 95: 301. doi:10.1007/s11060-009-9946-9

Abstract

Extended survival of 3 or more years is rare in patients with glioblastoma (GBM) but is becoming more common. Clinical outcome has not been well studied. We reviewed GBM patients at Memorial Sloan-Kettering Cancer Center between 2001 and 2003 who were seen for two or more visits. Patient characteristics and long-term clinical outcomes were reviewed for patients who had survived 3 or more years following diagnosis. Thirty-nine (11%) of 352 GBM patients were identified as long-term survivors. Median survival was 9.15 years (range: 3–18 years). Median age was 47 years (range: 16–69); 13% were 65 years or older. Median KPS was 90 (range: 50–100). One long-term survivor underwent biopsy alone; 19 patients each had either complete or subtotal resection. All received focal radiotherapy (RT) with a median dose of 5940 cGy; 18% received concurrent temozolomide. Adjuvant chemotherapy was administered to 35 (90%). Twelve patients (31%) remained in continuous remission. Twenty-seven had tumor progression a median of 29.2 months after diagnosis (range: 1.2–167 months); 18 had multiple relapses. Median KPS at last follow-up was 70 (range: 40–100); 85% of long-term survivors had at least one significant neurologic deficit. Eleven (28%) had clinically significant RT-induced leukoencephalopathy, 9 (23%) developed RT necrosis and 9 (23%) treatment-related strokes. Treatment-related complications occurred a median of 2.7 years from diagnosis (range: 0.9–11.5 years). Long-term survivors remain rare, but are found across all age groups despite multiple recurrences; clinically significant delayed complications of treatment are common.

Keywords

Glioblastoma Long-term survivors Quality of life 

Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • Andreas F. Hottinger
    • 1
  • Hannah Yoon
    • 1
  • Lisa M. DeAngelis
    • 1
  • Lauren E. Abrey
    • 1
  1. 1.Department of NeurologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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