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Journal of Neuro-Oncology

, Volume 98, Issue 3, pp 407–409 | Cite as

Multiple sclerosis attacks triggered by hyperprolactinemia

  • V. Nociti
  • G. Frisullo
  • T. Tartaglione
  • A. K. Patanella
  • R. Iorio
  • P. A. Tonali
  • A. P. BatocchiEmail author
Case Report

Abstract

Multiple sclerosis (MS) is a T-cell autoimmune disease of the central nervous system (CNS). Predominance of women in autoimmune diseases suggests that sex hormones may play a role in disease susceptibility. A possible role for prolactin, a neuroendocrine peptide with powerful immunomodulatory properties, is suggested in MS. We describe the case of a 32-year-old man affected by relapsing-remitting MS who experienced the first MS clinical event during the development of a prolactin-secreting adenoma and the only two MS relapses during adenoma recurrence. Prolactin may have facilitated the inflammatory process and triggered MS clinical attacks, suggesting a role of prolactin in immunomodulation and therefore in autoimmune disease course.

Keywords

Multiple sclerosis Prolactin Prolactin-secreting adenoma Cytokines Immune system 

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Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • V. Nociti
    • 1
    • 3
  • G. Frisullo
    • 1
  • T. Tartaglione
    • 2
  • A. K. Patanella
    • 1
    • 3
  • R. Iorio
    • 1
  • P. A. Tonali
    • 1
    • 3
  • A. P. Batocchi
    • 1
    • 3
    Email author
  1. 1.Institute of Neurology, Department of NeurosciencesCatholic UniversityRomeItaly
  2. 2.Institute of Radiology, Department of Bioimaging and Radiological SciencesCatholic UniversityRomeItaly
  3. 3.Fondazione Don GnocchiRomeItaly

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