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Journal of Neuro-Oncology

, Volume 97, Issue 3, pp 445–450 | Cite as

A surgically treated case of Lhermitte–Duclos disease with a precise natural history and high uptake of FDG on PET

  • Yuko Goto
  • Naoya HashimotoEmail author
  • Yoshiko Okita
  • Tetsu Goto
  • Carter Rabo
  • Hiroshi Hirayama
  • Yoshiharu Horikawa
  • Manabu Kinoshita
  • Naoki Kagawa
  • Toshiki Yoshimine
Case Report

Abstract

We describe herein a surgically treated case of Lhermitte–Duclos disease in a 33-year-old man. The clinical presentation seemed typical in terms of symptoms, neurological signs, and neuroimaging. High and heterogenous fluorodeoxyglucose uptake in positron emission tomography study is presented and discussed. Furthermore, we performed volumetric analysis of the tumor with sequential magnetic resonance imaging over the course of 7 years before surgery, making this report the first with a long-term natural history, revealing that this rare disease entity may have a neoplastic nature.

Keywords

Lhermitte–Duclos disease FDG-PET Volumetry Natural history 

Notes

Acknowledgements

We thank Ms. R. Fujita for her technical assistance, and Ms. M. Kakinoki for assistance with the manuscript.

Disclosure

This work was supported in part by Grants-in Aid No. 20591685 for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan, to Naoya Hashimoto, M.D., Ph.D.

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Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • Yuko Goto
    • 1
  • Naoya Hashimoto
    • 1
    Email author
  • Yoshiko Okita
    • 1
  • Tetsu Goto
    • 1
  • Carter Rabo
    • 1
  • Hiroshi Hirayama
    • 2
  • Yoshiharu Horikawa
    • 2
  • Manabu Kinoshita
    • 1
  • Naoki Kagawa
    • 1
  • Toshiki Yoshimine
    • 1
  1. 1.Department of NeurosurgeryOsaka University Graduate School of MedicineSuitaJapan
  2. 2.Suita Saiseikai HospitalSuitaJapan

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