Journal of Neuro-Oncology

, Volume 91, Issue 2, pp 207–212 | Cite as

Hypofractionated stereotactic radiotherapy in combination with whole brain radiotherapy for brain metastases

  • Cesare Giubilei
  • Gianluca Ingrosso
  • Marco D’Andrea
  • Michaela Benassi
  • Riccardo Santoni
Clinical study - patient study

Abstract

Background The efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) in combination with whole brain radiotherapy (WBRT), for the treatment of 1–4 brain metastases, using a non invasive fixation of the skull, was investigated. Methods Between 04/2001 and 01/2006 30 patients with 44 brain metastases underwent irradiation. Every patient received WBRT (10 × 3 Gy); 41/44 lesions received HSRT boost with a median dose fraction of 6 Gy, the fractionation schemes were 3 × 6 Gy and 4 × 8 Gy; a median total dose of 18 Gy was delivered to the tumor isocenter. Results The median survival period was 9.15 months, the actuarial 1-year overall survival and freedom from new brain metastases were 36.6% and 87.9%, respectively; at univariate analysis Karnofsky Performance Status (KPS) was statistically significant (P = 0.05); the actuarial 1-year local control for the 41/44 lesions was 86.1%. No patient had acute or late complications. Conclusions HSRT as a concomitant boost during WBRT is a safe and well tolerated treatment for selected patients with brain metastases.

Keywords

Brain metastases Hypofractionated stereotactic radiotherapy Whole brain radiotherapy Prognostic factors Local control Radiobiology 

Abbreviations

HSRT

Hypofractionated stereotactic radiotherapy

SRS

Stereotactic radio-surgery

WBRT

Whole brain radiotherapy

KPS

Karnofsky performance status

BED

Biologic effective dose

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Cesare Giubilei
    • 1
  • Gianluca Ingrosso
    • 1
  • Marco D’Andrea
    • 1
  • Michaela Benassi
    • 1
  • Riccardo Santoni
    • 1
  1. 1.Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and RadiotherapyTor Vergata University General HospitalRomeItaly

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