Journal of Neuro-Oncology

, 91:199 | Cite as

Survival benefit of Boron neutron capture therapy for recurrent malignant gliomas

  • Shin-Ichi MiyatakeEmail author
  • Shinji Kawabata
  • Kunio Yokoyama
  • Toshihiko Kuroiwa
  • Hiroyuki Michiue
  • Yoshinori Sakurai
  • Hiroaki Kumada
  • Minoru Suzuki
  • Akira Maruhashi
  • Mitsunori Kirihata
  • Koji Ono
Clinical study - patient Study


We have applied boron neutron capture therapy (BNCT) to malignant brain tumors. Here we evaluated the survival benefit of BNCT for recurrent malignant glioma (MG). Since 2002, we have treated 22 cases of recurrent MG with BNCT. Survival time was analyzed with special reference to recursive partitioning analysis (RPA) classification, by Carson et al. (J Clin Oncol 25:2601–2606, 2007). Median survival times (MSTs) after BNCT for all patients and for glioblastoma as on-study histology at recurrence was 10.8 months (n = 22; 95% CI, 7.3–12.8 months) and 9.6 months (n = 19; 95% CI, 6.9–11.4 months), respectively. In our study, MST for the high-risk RPA classes was 9.1 months (n = 11; 95% CI, 4.4–11.0 months). By contrast, the original journal data showed that the MST of the same RPA classes was 4.4 months (n = 129; 95% CI, 3.6–5.4 months). BNCT showed a survival benefit for recurrent MG, especially in the high-risk group.





This work was partly supported by Grants-in-Aid for Scientific Research (B) (16390422 and 19390385) from the Japanese Ministry of Education, Science and Culture, by a Grant-in-Aid for Scientific Research from the Ministry of Health, Labor and Welfare of Japan to S–I.M. (P·I., Hideki Matsui) and by the Regional Science Promotion Program of the Japan Science and Technology Corporation, as well as by the “Second-term Comprehensive 10-Year Strategy for Cancer Control” of the Ministry of Health, Labor, and Welfare of Japan to S–I.M. This work was also supported in part by the Takeda Science Foundation for Osaka Medical College, by a Grant-in-Aid for Cancer Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (12217065) to K. O., and by Grants-in-Aid for Scientific Research by young researchers (B) (18791030) from the Japanese Ministry of Education, Science, and Culture to S. K. The top two authors contributed equally in this study as primary co-investigators.

Supplementary material

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Shin-Ichi Miyatake
    • 1
    • 2
    Email author
  • Shinji Kawabata
    • 1
  • Kunio Yokoyama
    • 1
  • Toshihiko Kuroiwa
    • 1
  • Hiroyuki Michiue
    • 3
  • Yoshinori Sakurai
    • 4
  • Hiroaki Kumada
    • 5
  • Minoru Suzuki
    • 4
  • Akira Maruhashi
    • 4
  • Mitsunori Kirihata
    • 6
  • Koji Ono
    • 4
  1. 1.Department of NeurosurgeryOsaka Medical CollegeTakatsukiJapan
  2. 2.Cancer Intelligence Care System, Inc.TokyoJapan
  3. 3.Department of NeurosurgeryOkayama UniversityOkayamaJapan
  4. 4.Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto UniversityKumatoriJapan
  5. 5.Department of Research Reactor and Tandem Accelerator, Nuclear Science Institute, Japan Atomic Energy AgencyTokaiJapan
  6. 6.Department of AgricultureOsaka Prefectural UniversitySakaiJapan

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