Journal of Neuro-Oncology

, Volume 90, Issue 1, pp 25–30 | Cite as

Long-term outcome of conventional radiation therapy for central neurocytoma

  • Sun Ha Paek
  • Jung-Ho Han
  • Jin Wook Kim
  • Chul-Kee Park
  • Hee-Won Jung
  • Sung-Hye Park
  • Il Han Kim
  • Dong Gyu KimEmail author
Clinical-Patienet Studies


The authors report the long-term outcome of conventional radiation therapy (RT) in six cases of central neurocytoma (CN). Between 1985 and 1992, six patients were treated with RT for residual tumors or for prevention of recurrence after surgery. The median follow-up period of radiological and clinical status were 171 (range: 128–229) and 202 months (range: 165–227), respectively. Tumors disappeared in three and reduced in three patients at the last follow-up. One-mortality case due to radiation necrosis and one radiation-induced malignancy occurred. White matter degeneration and cortical atrophy were noticed with slow progression of performance deterioration in two patients. Conventional RT seemed to effectively control residual CN after surgery. However, more sophisticated radiation techniques should be applied to minimize the late sequela.


Central neurocytoma Conventional radiation therapy Long-term outcome 



This work was partially supported by a grant from Cancer Research Institute of Seoul National University and Clinical Research institute of Seoul National University Hospital.


  1. 1.
    Hassoun J, Gambarelli D, Grisoli F et al (1982) Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol 56:151–156CrossRefPubMedGoogle Scholar
  2. 2.
    Kim DG, Chi JG, Park SH et al (1992) Intraventricular neurocytoma: clinicopathological analysis of seven cases. J Neurosurg 76:759–765CrossRefPubMedGoogle Scholar
  3. 3.
    Bertalanffy A, Roessler K, Koperek O et al (2005) Recurrent central neurocytomas. Cancer 104:135–142CrossRefPubMedGoogle Scholar
  4. 4.
    Kim DG, Paek SH, Kim IH et al (1997) Central neurocytoma: the role of radiation therapy and long term outcome. Cancer 79:1995–2002CrossRefPubMedGoogle Scholar
  5. 5.
    Kulkarni V, Rajshekhar V, Haran RP et al (2002) Long-term outcome in patients with central neurocytoma following stereotactic biopsy and radiation therapy. Br J Neurosurg 16:126–132CrossRefPubMedGoogle Scholar
  6. 6.
    Nakagawa K, Aoki Y, Sakata K et al (1993) Radiation therapy of well-differentiated neuroblastoma and central neurocytoma. Cancer 72:1350–1355CrossRefPubMedGoogle Scholar
  7. 7.
    Rades D, Schild SE, Ikezaki K et al (2003) Defining the optimal dose of radiation after incomplete resection of central neurocytomas. Int J Radiat Oncol Biol Phys 55:373–377CrossRefPubMedGoogle Scholar
  8. 8.
    Fujimaki T, Matsuno A, Sasaki T et al (1997) Proliferative activity of central neurocytoma: measurement of tumor volume doubling time, MIB-1 staining index and bromodeoxyuridine labeling index. J Neurooncol 32:103–109CrossRefPubMedGoogle Scholar
  9. 9.
    Pollock BE, Stafford SL (2001) Stereotactic radiosurgery for recurrent central neurocytoma: case report. Neurosurgery 48:441–443CrossRefPubMedGoogle Scholar
  10. 10.
    Becker M, Schroth G, Zbaren P et al (1997) Long-term changes induced by high-dose irradiation of the head and neck region: imaging findings. Radiographics 17:5–26PubMedGoogle Scholar
  11. 11.
    Anderson RC, Elder JB, Parsa AT et al (2001) Radiosurgery for the treatment of recurrent central neurocytomas. Neurosurgery 48:1231–1237. discussion 1237–1238CrossRefPubMedGoogle Scholar
  12. 12.
    Bertalanffy A, Roessler K, Dietrich W et al (2001) Gamma knife radiosurgery of recurrent central neurocytomas: a preliminary report. J Neurol Neurosurg Psychiatry 70:489–493CrossRefPubMedGoogle Scholar
  13. 13.
    Cobery ST, Noren G, Friehs GM et al (2001) Gamma knife surgery for treatment of central neurocytomas. Report of four cases. J Neurosurg 94:327–330CrossRefPubMedGoogle Scholar
  14. 14.
    Hara M, Aoyagi M, Yamamoto M et al (2003) Rapid shrinkage of remnant central neurocytoma after gamma knife radiosurgery: a case report. J Neurooncol 62:269–273CrossRefPubMedGoogle Scholar
  15. 15.
    Javedan SP, Manwaring K, Smith KA (2003) Treatment of posterior third ventricular central neurocytoma with endoscopic biopsy, endoscopic third ventriculostomy and stereotactic radiosurgery. Minim Invasive Neurosurg 46:165–168CrossRefPubMedGoogle Scholar
  16. 16.
    Kim CY, Paek SH, Kim DG (2003) Linear accelerator radiosurgery for central neurocytoma: a case report. J Neurooncol 61:249–254CrossRefPubMedGoogle Scholar
  17. 17.
    Martin JM, Katati M, Lopez E et al (2003) Linear accelerator radiosurgery in treatment of central neurocytomas. Acta Neurochir (Wien) 145:749–754. discussion 754CrossRefGoogle Scholar
  18. 18.
    Maruyama I, Sadato N, Waki A et al (1999) Hyperacute changes in glucose metabolism of brain tumors after stereotactic radiosurgery: a PET study. J Nucl Med 40:1085–1090PubMedGoogle Scholar
  19. 19.
    Moussa R, Abadjian G, Nader M et al (2004) Central neurocytoma. Four patients. Neurochirurgie 50:639–646CrossRefPubMedGoogle Scholar
  20. 20.
    Leenstra JL, Rodriguez FJ, Frechette CM et al (2007) Central neurocytoma: management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys 67:1145–1154CrossRefPubMedGoogle Scholar
  21. 21.
    Rades D, Schild SE (2006) Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas. Cancer 106:1140–1143CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Sun Ha Paek
    • 1
  • Jung-Ho Han
    • 1
  • Jin Wook Kim
    • 1
  • Chul-Kee Park
    • 1
  • Hee-Won Jung
    • 1
  • Sung-Hye Park
    • 2
  • Il Han Kim
    • 3
  • Dong Gyu Kim
    • 1
    Email author
  1. 1.Department of NeurosurgerySeoul National University College of Medicine, Cancer Research Center, Seoul National University, Clinical Research Institute, Seoul National University HospitalSeoulKorea
  2. 2.Department of PathologySeoul National University College of Medicine, Seoul National University, Clinical Research Institute, Seoul National University HospitalSeoulKorea
  3. 3.Department of Radiation OncologySeoul National University College of Medicine, Seoul National University, Clinical Research Institute, Seoul National University HospitalSeoulKorea

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