Journal of Neuro-Oncology

, 89:313 | Cite as

Radiation therapy of pathologically confirmed newly diagnosed glioblastoma in adults

  • John Buatti
  • Timothy C. Ryken
  • Mark C. Smith
  • Penny Sneed
  • John H. Suh
  • Minesh Mehta
  • Jeffrey J. Olson
Invited Manuscript


Level 1

Radiation therapy is recommended for the treatment of newly diagnosed malignant glioma in adults. Treatment schemes should include dosage of up to 60 Gy given in 2 Gy daily fractions that includes the enhancing area.

Hypo-fractionated radiation schemes may be used for patients with a poor prognosis and limited survival without compromising response.

Hyper-fractionation and accelerated fractionation have not been shown to be superior to conventional fractionation and are not recommended.

Brachytherapy or stereotactic radiosurgery as a boost to external beam radiotherapy have not been shown to be beneficial and are not recommended in the routine management of newly diagnosed malignant glioma.

Level 2

It is recommended that radiation therapy planning include a 1–2 cm margin around the radiographically defined T1 contrast-enhancing tumor volume or the T2 weighted abnormality on MR imaging.


Although radiation therapy has been a standard therapy for the...


Malignant Glioma Karnofsky Performance Status BCNU Radiation Therapy Oncology Group Brain Radiotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We wish to acknowledge Stephen Haines, MD, Jack Rock, MD, and Tom Mikkelson, MD for their review and consultations regarding on this work. The authors also wish to express appreciation to the AANS/CNS Joint Guidelines Committee for their review, comments and suggestions. We also thank Linda Phillips for meeting organization and collection of materials and Emily Feinstein for her assistance in editing the material for publication.


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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • John Buatti
    • 1
  • Timothy C. Ryken
    • 2
  • Mark C. Smith
    • 3
  • Penny Sneed
    • 4
  • John H. Suh
    • 5
  • Minesh Mehta
    • 6
  • Jeffrey J. Olson
    • 7
  1. 1.Department of Radiation OncologyUniversity of IowaIowa CityUSA
  2. 2.Department of NeurosurgeryUniversity of Iowa College of MedicineIowa CityUSA
  3. 3.Department of Radiation OncologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA
  4. 4.Department of Radiation OncologyUniversity of CaliforniaSan FranciscoUSA
  5. 5.Department of Radiation OncologyCleveland Clinic FoundationClevelandUSA
  6. 6.Department of Radiation OncologyUniversity of WisconsinMadisonUSA
  7. 7.Department of NeurosurgeryEmory University School of MedicineAtlantaUSA

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