Journal of Neuro-Oncology

, Volume 89, Issue 2, pp 225–230 | Cite as

99mTc-Tetrofosmin brain SPECT in the assessment of meningiomas—correlation with histological grade and proliferation index

  • Andreas D. Fotopoulos
  • George A. Alexiou
  • Ann Goussia
  • Athanasios Papadopoulos
  • Athanasios P. Kyritsis
  • Konstantinos S. Polyzoidis
  • Spyridon Voulgaris
  • Spyridon Tsiouris
Clinical-patient studies

Abstract

Meningiomas account for about 30% of all intracranial tumors. Evaluation of their proliferation rate is useful for assessing their biological behavior. We evaluated prospectively whether 99mTc-Tetrofosmin (99mTc-TF) uptake in meningiomas correlates with cellular proliferative activity and with tumor grade. We prospectively studied 18 meningioma cases. Brain single-photon emission computed tomography (SPECT) by 99mTc-TF was performed within a week prior to surgical excision. In the excised tumor specimens we assessed Ki-67 antigen expression. 14 of 18 patients had benign meningiomas, while the remaining four had anaplastic meningiomas. A significant correlation was found between both 99mTc-TF uptake and tumor grade (r = 0.722, P = 0.001) and between 99mTc-TF uptake and Ki-67 expression (r = 0.930, P < 0.001). There was a significant correlation between the intensity of tracer uptake and tumor recurrence at 1 year postoperative (r = 0.574, P = 0.02). This pilot study implies that 99mTc-TF brain SPECT could prove useful in differentiating benign from anaplastic meningiomas and is a potential indicator of their proliferative activity.

Keywords

Meningioma 99mTc-Tetrofosmin Cell proliferation Ki-67 MIB-1 

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Andreas D. Fotopoulos
    • 1
  • George A. Alexiou
    • 2
  • Ann Goussia
    • 3
  • Athanasios Papadopoulos
    • 1
  • Athanasios P. Kyritsis
    • 4
  • Konstantinos S. Polyzoidis
    • 2
  • Spyridon Voulgaris
    • 2
  • Spyridon Tsiouris
    • 1
  1. 1.Department of Nuclear MedicineUniversity of Ioannina School of MedicineIoanninaGreece
  2. 2.Department of NeurosurgeryUniversity of Ioannina School of MedicineIoanninaGreece
  3. 3.Department of PathologyUniversity of Ioannina School of MedicineIoanninaGreece
  4. 4.Department of NeurologyUniversity of Ioannina School of MedicineIoanninaGreece

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