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Journal of Neuro-Oncology

, Volume 86, Issue 2, pp 217–224 | Cite as

A supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature

  • Shigeo Ohba
  • Kazunari Yoshida
  • Yuichi Hirose
  • Eiji Ikeda
  • Takeshi Kawase
Clinical-patient studies

Abstract

Supratentorial primitive neuroectodermal tumors (sPNET) occurring in adults are rare. Only 56 such cases have been previously reported. This report documents a 56-year-old male who presented with the chief complaint of right facial palsy. Magnetic resonance imaging (MRI) revealed left frontal and bilateral periventricular lesions. Surgery was performed for the frontal mass, which was histologically diagnosed to be sPNET. An immunohistochemistry assay for CD99, and a fluorescence in situ hybridization (FISH) assay for t(11;22) translocation revealed this PNET to be a central PNET. This case was the first case to detect a central PNET using both immunohistochemistry and the FISH assay in adult sPNET. Though radiation therapy was performed, an MRI performed 2.5 months after the surgery revealed a regrowth of the tumor. The patient died 5 months after surgery. This case report is accompanied by a review of 57 cases of adult sPNET.

Keywords

Adult CD99 Central PNET FISH Supratentorial primitive neuroectodermal tumor t(11;22) 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Shigeo Ohba
    • 1
  • Kazunari Yoshida
    • 1
  • Yuichi Hirose
    • 2
  • Eiji Ikeda
    • 3
  • Takeshi Kawase
    • 1
  1. 1.Department of NeurosurgeryKeio University School of MedicineShinjuku-kuJapan
  2. 2.Department of NeurosurgeryFujita Health UniversityToyoakeJapan
  3. 3.Department of PathologyKeio University School of MedicineShinjuku-kuJapan

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