Journal of Neuro-Oncology

, Volume 86, Issue 1, pp 71–78 | Cite as

Cellular phone use and brain tumor: a meta-analysis

  • Peter Kan
  • Sara E. Simonsen
  • Joseph L. Lyon
  • John R. W. Kestle
Clinical Study - Patient Studies

Abstract

Background

The dramatic increase in the use of cellular phones has generated concerns about potential adverse effects, especially the development of brain tumors. We conducted a meta-analysis to examine the effect of cellular phone use on the risk of brain tumor development.

Methods

We searched the literature using MEDLINE to locate case-control studies on cellular phone use and brain tumors. Odds ratios (ORs) for overall effect and stratified ORs associated with specific brain tumors, long-term use, and analog/digital phones were calculated for each study using its original data. A pooled estimator of each OR was then calculated using a random-effects model.

Results

Nine case-control studies containing 5,259 cases of primary brain tumors and 12,074 controls were included. All studies reported ORs according to brain tumor subtypes, and five provided ORs on patients with ≥10 years of follow up. Pooled analysis showed an overall OR of 0.90 (95% confidence interval [CI] 0.81–0.99) for cellular phone use and brain tumor development. The pooled OR for long-term users of ≥10 years (5 studies) was 1.25 (95% CI 1.01–1.54). No increased risk was observed in analog or digital cellular phone users.

Conclusions

We found no overall increased risk of brain tumors among cellular phone users. The potential elevated risk of brain tumors after long-term cellular phone use awaits confirmation by future studies.

Keywords

Brain tumors Cellular phones Radiation 

References

  1. 1.
    National Radiological Protection Board (2004) Mobile phones and health 2004. Report of the Board of NRPB. NRPB, OxonGoogle Scholar
  2. 2.
    Anderson V (2003) Comparisons of peak SAR levels in concentric sphere head models of children and adults for irradiation by a dipole at 900 MHz. Phys Med Biol 48:3263–3275PubMedCrossRefGoogle Scholar
  3. 3.
    Hermann DM, Hossmann KA (1997) Neurological effects of microwave exposure related to mobile communication. J Neurol Sci 152:1–14PubMedCrossRefGoogle Scholar
  4. 4.
    Moulder JE, Erdreich LS, Malyapa RS et al (1999) Cell phones and cancer: what is the evidence for a connection? Radiat Res 151:513–531PubMedCrossRefGoogle Scholar
  5. 5.
    Valberg PA (1997) Radio frequency radiation (RFR): the nature of exposure and carcinogenic potential. Cancer Causes Control 8:323–332PubMedCrossRefGoogle Scholar
  6. 6.
    Auvinen A, Hietanen M, Luukkonen R et al (2002) Brain tumors and salivary gland cancers among cellular telephone users. Epidemiology 13:356–359PubMedCrossRefGoogle Scholar
  7. 7.
    Christensen HC, Schuz J, Kosteljanetz M et al (2005) Cellular telephones and risk for brain tumors: a population-based, incident case-control study. Neurology 64:1189–1195PubMedGoogle Scholar
  8. 8.
    Hepworth SJ, Schoemaker MJ, Muir KR et al (2006) Mobile phone use and risk of glioma in adults: case-control study. BMJ 332:883–887PubMedCrossRefGoogle Scholar
  9. 9.
    Inskip PD, Tarone RE, Hatch EE et al (2001) Cellular-telephone use and brain tumors. N Engl J Med 344:79–86PubMedCrossRefGoogle Scholar
  10. 10.
    Lonn S, Ahlbom A, Hall P et al (2005) Long-term mobile phone use and brain tumor risk. Am J Epidemiol 161:526–535PubMedCrossRefGoogle Scholar
  11. 11.
    Muscat JE, Malkin MG, Thompson S et al (2000) Handheld cellular telephone use and risk of brain cancer. JAMA 284:3001–3007PubMedCrossRefGoogle Scholar
  12. 12.
    Schoemaker MJ, Swerdlow AJ, Ahlbom A et al (2005) Mobile phone use and risk of acoustic neuroma: results of the Interphone case-control study in five North European countries. Br J Cancer 93:842–848PubMedCrossRefGoogle Scholar
  13. 13.
    Schuz J, Bohler E, Berg G et al (2006) Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group, Germany). Am J Epidemiol 163:512–520PubMedCrossRefGoogle Scholar
  14. 14.
    Hardell L, Mild KH, Carlberg M (2002) Case-control study on the use of cellular and cordless phones and the risk for malignant brain tumours. Int J Radiat Biol 78:931–936PubMedCrossRefGoogle Scholar
  15. 15.
    Lonn S, Ahlbom A, Hall P et al (2004) Mobile phone use and the risk of acoustic neuroma. Epidemiology 15:653–659PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Peter Kan
    • 1
  • Sara E. Simonsen
    • 2
  • Joseph L. Lyon
    • 2
  • John R. W. Kestle
    • 1
  1. 1.Division of Pediatric Neurosurgery, Department of NeurosurgeryUniversity of UtahSalt Lake CityUSA
  2. 2.Department of Family and Preventive MedicineUniversity of UtahSalt Lake CityUSA

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