Journal of Neuro-Oncology

, Volume 85, Issue 3, pp 281–287 | Cite as

Low HER2-expressing glioblastomas are more often secondary to anaplastic transformation of low-grade glioma

  • Jean-François Mineo
  • Anne Bordron
  • Marc Baroncini
  • Claude-Alain Maurage
  • Carole Ramirez
  • Rose-Mary Siminski
  • Christian Berthou
  • Phong Dam Hieu
Lab Investigation-Human/Animal Tissue

Abstract

Background

Anti-Human Epithelial Receptor Type 2 (HER2) antibodies have the ability to induce in vitro apoptosis of glioblastoma (GBM) cells. This study was designed to evaluate the variability of HER2 expression in GBM and its role as a possible prognosis factor.

Methods

Data of 57 patients with GBM and 16 patients with grade III gliomas were retrospectively analyzed. The expression of HER2 was determined by immunohistochemistry and intensity was noted from 0+ to 3+. We compared the HER2 expression in de novo GBM and in GBM resulting from anaplastic transformation of low-grade glioma (“secondary GBM”). Statistical analysis was performed using univariate analysis and the Kaplan–Meier method.

Findings

All GBM expressing highly HER2 (2+ and 3+) were de novo GBM. All secondary GBM expressed HER2 with low intensity (0+ and 1+). Survival time was significantly longer when HER2 expression was low (Log Rank test P = 0.04). The patterns of HER2 expression were similar between grade III gliomas and secondary GBM.

Conclusions

To our best knowledge, our study showed for the first time a significant association between HER2 expression and the type of GBM, with subsequent influence on survival rate. GBM with low-HER2 expression are more likely to be secondary GBM, carrying a better prognosis than de novo GBM.

Keywords

Glioblastoma De novo glioblastoma Secondary glioblastoma HER2 Survival 

Abbreviations

BBB

Blood Brain barrier

GBM

Glioblastoma

HER2

Human Epithelial Receptor Type 2

IHC

Immunohistochemistry

TMA

Tissue Micro array

WHO

World Health Organization

MGMT

O6-methyl guanine-DNA methyl transferase

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Jean-François Mineo
    • 1
  • Anne Bordron
    • 2
  • Marc Baroncini
    • 1
  • Claude-Alain Maurage
    • 3
  • Carole Ramirez
    • 1
  • Rose-Mary Siminski
    • 4
  • Christian Berthou
    • 2
  • Phong Dam Hieu
    • 5
  1. 1.Department of NeurosurgeryUniversity Medical Center, Hospital Roger SalengroLilleFrance
  2. 2.Laboratory of Cell Therapy and HematologyUniversity Medical CenterBrestFrance
  3. 3.Laboratory of Pathology, EurasanteUniversity Medical CenterLilleFrance
  4. 4.Laboratory of HistologyUniversity Medical CenterLilleFrance
  5. 5.Department of NeurosurgeryUniversity Medical CenterBrestFrance

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