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Journal of Neuro-Oncology

, Volume 85, Issue 1, pp 81–85 | Cite as

Loss of heterozygosity studies in extracranial metastatic meningiomas

  • Caroline Regna Gladin
  • Ettore Salsano
  • Francesca Menghi
  • Marina Grisoli
  • Francesco Ghielmetti
  • Ida Milanesi
  • Bianca Pollo
  • Stefano Brock
  • Alberto Cusin
  • Ludovico Minati
  • Gaetano Finocchiaro
  • Maria Grazia Bruzzone
Clinical-Patien Studies

Abstract

Although most meningiomas are slow-growing tumours associated with favourable prognosis, they often present local recurrence after surgical treatment; by contrast, extracranial metastatic meningiomas are rare, occurring in less than 1% of the cases. Risk factors for distal spread remain largely unknown. We report three cases with lung or bone metastases from intracranial recurrent meningiomas. Loss of heterozygosity (LOH) analysis on 1p, 9p, 10q, 14q, and 22q was conducted in available primary, recurrent and metastatic lesions, showing the same LOH pattern in the distal metastases and in the intracranial meningioma. LOH at 1p, 14q and 9p, known to be associated with increased aggressiveness, were found. The results highlight the potential clinical relevance of integrating histopathological studies with molecular genetic analysis in the follow-up of patients with different types of meningiomas.

Keywords

Meningioma Metastasis Loss of heterozygosity 

Notes

Acknowledgements

This work was partially supported by grants from the “Associazione Italiana per la Ricerca contro il Cancro” and “Ministero della Salute” to GF.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Caroline Regna Gladin
    • 1
  • Ettore Salsano
    • 1
  • Francesca Menghi
    • 1
  • Marina Grisoli
    • 1
  • Francesco Ghielmetti
    • 1
  • Ida Milanesi
    • 2
  • Bianca Pollo
    • 3
  • Stefano Brock
    • 2
  • Alberto Cusin
    • 2
  • Ludovico Minati
    • 1
  • Gaetano Finocchiaro
    • 1
  • Maria Grazia Bruzzone
    • 1
    • 4
  1. 1.Department of Experimental Neurology and DiagnosticsFondazione IRCCS Istituto Neurologico BestaMilanoItaly
  2. 2.Department of NeurosurgeryFondazione IRCCS Istituto Neurologico BestaMilanoItaly
  3. 3.Department of Clinical NeurologyFondazione IRCCS Istituto Neurologico BestaMilanoItaly
  4. 4.Unit of Neuro-RadiologyFondazione IRCCS Istituto Neurologico BestaMilanoItaly

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