Journal of Neuro-Oncology

, Volume 85, Issue 1, pp 77–79 | Cite as

Unexpected dementia following prophylactic cranial irradiation for small cell lung cancer: case report

  • David J. D’Ambrosio
  • Roger B. Cohen
  • Jon Glass
  • Andre Konski
  • Mark K. Buyyounouski
  • Steven J. Feigenberg
Clinical-Patient Studies

Abstract

Object

Prophylactic cranial irradiation (PCI) is commonly offered to patients with limited stage primary small cell lung cancer following a complete response.

Methods

We present the unique case of a 76-year-old woman treated with PCI with a dose of 30 Gy in 15 fractions, at 200 cGy per fraction who developed progressive dementia.

Conclusions

This is the first reported case of dementia from PCI at this low dose per fraction. Patients need to be counseled regarding the risks and benefits of treatment, including dementia with treatment and risk of sequelae from CNS metastasis without treatment. The authors review the data supporting PCI and the incidence of radiation associated dementia.

Keywords

Brain Dementia Prophylactic Cranial Irradiation PCI Radiation Small cell lung cancer 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • David J. D’Ambrosio
    • 1
  • Roger B. Cohen
    • 2
  • Jon Glass
    • 3
  • Andre Konski
    • 1
  • Mark K. Buyyounouski
    • 1
  • Steven J. Feigenberg
    • 1
  1. 1.Department of Radiation OncologyFox Chase Cancer CenterPhiladelphiaUSA
  2. 2.Department of Medical OncologyFox Chase Cancer CenterPhiladelphiaUSA
  3. 3.Department of NeurooncologyFox Chase Cancer CenterPhiladelphiaUSA

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