Journal of Neuro-Oncology

, Volume 83, Issue 1, pp 91–93

Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme

  • Ramon Martinez
  • Gabriele Schackert
  • Ricard Yaya-Tur
  • Iñigo Rojas-Marcos
  • James G. Herman
  • Manel Esteller
Letter to the Editor

DOI: 10.1007/s11060-006-9292-0

Cite this article as:
Martinez, R., Schackert, G., Yaya-Tur, R. et al. J Neurooncol (2007) 83: 91. doi:10.1007/s11060-006-9292-0

Abstract

We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Ramon Martinez
    • 1
    • 6
  • Gabriele Schackert
    • 1
  • Ricard Yaya-Tur
    • 2
  • Iñigo Rojas-Marcos
    • 3
  • James G. Herman
    • 4
  • Manel Esteller
    • 5
  1. 1.Department of NeurosurgeryUniversity of DresdenDresdenGermany
  2. 2.Medical Oncology Department of ValenciaValenciaSpain
  3. 3.Neurology DepartmentHôpital Pitié-SalpetrièreParisFrance
  4. 4.The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins UniversityBaltimoreUSA
  5. 5.Cancer Epigenetics LaboratorySpanish National Cancer Centre (CNIO)MadridSpain
  6. 6.Department of Neurosurgery, Klinikum FuldaAcad. Hospital Philipps University of MarburgFuldaGermany

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