Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme
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- Martinez, R., Schackert, G., Yaya-Tur, R. et al. J Neurooncol (2007) 83: 91. doi:10.1007/s11060-006-9292-0
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We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.