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Journal of Neuro-Oncology

, Volume 83, Issue 1, pp 91–93 | Cite as

Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme

  • Ramon Martinez
  • Gabriele Schackert
  • Ricard Yaya-Tur
  • Iñigo Rojas-Marcos
  • James G. Herman
  • Manel Esteller
Letter to the Editor

Abstract

We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.

Keywords

Temozolomide Glioblastoma Multiforme MGMT Promoter Methylation MGMT Methylation Promoter Methylation Status 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, Baylin SB, Herman JG (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343:1350-1354PubMedCrossRefGoogle Scholar
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    Esteller M, Herman JG (2004) Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer. Oncogene 23:1–8PubMedCrossRefGoogle Scholar
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    Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JE, Hau P, Mirimanoff RO, Cairncross JG, Janzer RC, Stupp R (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997–1003PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Ramon Martinez
    • 1
    • 6
  • Gabriele Schackert
    • 1
  • Ricard Yaya-Tur
    • 2
  • Iñigo Rojas-Marcos
    • 3
  • James G. Herman
    • 4
  • Manel Esteller
    • 5
  1. 1.Department of NeurosurgeryUniversity of DresdenDresdenGermany
  2. 2.Medical Oncology Department of ValenciaValenciaSpain
  3. 3.Neurology DepartmentHôpital Pitié-SalpetrièreParisFrance
  4. 4.The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins UniversityBaltimoreUSA
  5. 5.Cancer Epigenetics LaboratorySpanish National Cancer Centre (CNIO)MadridSpain
  6. 6.Department of Neurosurgery, Klinikum FuldaAcad. Hospital Philipps University of MarburgFuldaGermany

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