Journal of Neuro-Oncology

, Volume 82, Issue 3, pp 289–295

Epidemiological survey of central nervous system germ cell tumors in Canadian children

  • D. Keene
  • D. Johnston
  • D. Strother
  • C. Fryer
  • A. S. Carret
  • B. Crooks
  • D. Eisenstat
  • A. Moghrabi
  • B. Wilson
  • J. Brossard
  • C. Mpofu
  • I. Odame
  • S. Zelcer
  • M. Silva
  • Y. Samson
  • J. Hand
  • E. Bouffet
Clinical–Patient Studies

DOI: 10.1007/s11060-006-9282-2

Cite this article as:
Keene, D., Johnston, D., Strother, D. et al. J Neurooncol (2007) 82: 289. doi:10.1007/s11060-006-9282-2

Abstract

Objectives

To determine the incidence and characteristics of pediatric patients with central nervous system (CNS) germ cell tumors (GCT) in Canada.

Method

A national retrospective review of hospital charts was done on all patients with CNS GCT diagnosed between 1990 and 2004. Patients had to be under age 18 years at the time of diagnosis of a CNS germ cell tumor and be a resident of Canada. Information extracted included age and year of diagnosis, pathological diagnosis, location of tumor, evidence of disseminated disease at time of diagnosis and biological markers.

Results

One hundred and twenty-one cases were identified (83 germinoma; 38 non-germinoma germ cell tumor). The mean annual incidence of CNS GCT was 1.06 per million children (0.7 per million for germinoma; 0.3 per million for NGGCT). Though yearly incidences varied, there was no clear trend to increased incidence. Male predominance was noted (2.4:1 for germinoma; 11:1 for NGGCT). The primary locations were the pineal and suprasellar regions. At the time of diagnosis, disseminated disease was not uncommon (22% germinoma; 32% NGGCT). β human gonadotrophin was elevated in the serum, cerebrospinal fluid (CSF) or both in 7% of patients with germinoma and 36% of patients with NGGCT. Elevation of α-fetoprotein in serum, CSF or both was seen in 34% of patients with NGGCT.

Conclusion

The incidence of CNS germ cell tumors in Canadian children is similar to that observed in other Western countries.

Keywords

Incidence Germ cell tumors Childhood 

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • D. Keene
    • 1
  • D. Johnston
    • 1
  • D. Strother
    • 2
  • C. Fryer
    • 3
  • A. S. Carret
    • 4
  • B. Crooks
    • 5
  • D. Eisenstat
    • 6
  • A. Moghrabi
    • 7
  • B. Wilson
    • 8
  • J. Brossard
    • 9
  • C. Mpofu
    • 10
  • I. Odame
    • 11
  • S. Zelcer
    • 12
  • M. Silva
    • 13
  • Y. Samson
    • 14
  • J. Hand
    • 15
  • E. Bouffet
    • 16
  1. 1.Division of Neurology, Department of PediatricsChildren’s Hospital of Eastern OntarioOttawaCanada
  2. 2.Alberta Children’s HospitalCalgaryCanada
  3. 3.British Columbia Children’s HospitalVancouverCanada
  4. 4.Montreal Children’s HospitalMontrealCanada
  5. 5.IWK Health CentreHalifaxCanada
  6. 6.Cancer Care ManitobaWinnipegCanada
  7. 7.St Justine’s HospitalMontrealCanada
  8. 8.Stollery Children’s HospitalEdmontonCanada
  9. 9.Centre Hospitalier Universitaire de SherbrookeSherbrookeCanada
  10. 10.Royal University HospitalSaskatoonCanada
  11. 11.McMaster Medical CenterHamiltonCanada
  12. 12.Children’s Hospital of Western OntarioLondonCanada
  13. 13.Kingston General HospitalKingstonCanada
  14. 14.Centre Hospitalier Universitaire de QuebecQuebec CityCanada
  15. 15.Janeway Child Health CenterSt John’sCanada
  16. 16.Hospital for Sick ChildrenTorontoCanada

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