Journal of Neuro-Oncology

, Volume 82, Issue 3, pp 249–256

Endoglin (CD 105) is expressed on endothelial cells in the primary central nervous system lymphomas and correlates with survival

  • Yasuo Sugita
  • Yukari Takase
  • Daisuke Mori
  • Osamu Tokunaga
  • Akihiko Nakashima
  • Minoru Shigemori
Laboratory Investigation

DOI: 10.1007/s11060-006-9281-3

Cite this article as:
Sugita, Y., Takase, Y., Mori, D. et al. J Neurooncol (2007) 82: 249. doi:10.1007/s11060-006-9281-3

Abstract

Endoglin (CD105) is predominantly expressed on the cellular lineages within the vascular system and it is overexpressed on proliferating endothelial cells that participate in neoangiogenesis, with a weak or negative expression in the vascular endothelium of normal tissues. To investigate the correlation between the CD105 expression and possible prognostic markers or progression in the primary central nervous system lymphomas (PCNSLs), the present study assessed 26 cases of PCNSL by immunostaining for CD105 and CD34. Intratumoral microvessel density (IMVD) was determined in the hotspots and interfaces at a magnification of x200. According to the mean value, the patients were classified into lower-IMVD and higher-IMVD groups. When CD34 was used as a marker of angiogenesis, the survival rates of these two groups demonstrated no significant difference. In contrast, when CD105 was used as a marker of angiogenesis, the survival rate of the lower-IMVD group was significantly higher than that for the higher-IMVD group (< 0.01). In the group of CD34-immunostained vessels, no difference was observed in IMVD between the hotspots and interfaces (P = 0.31). In the group with CD105-immunostained vessels, a greater IMVD was observed in the hotspots than in the interfaces (P < 0.01). These results suggested that the growth of PCNSLs was dependent on angiogenesis, that IMVD as determined by anti-CD105 monoclonal antibody was a reliable prognostic marker in PCNSLs, and that PCNSLs may therefore not require sufficient neoangiogenesis at the start of PCNSLs, however, it may instead require a higher rate of neoangiogenesis as they infiltrate and destroy the brain parenchyma.

Keywords

CD34 CD105 (endoglin) Central nervous system lymphomas Neoangiogenesis Prognosis 

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Yasuo Sugita
    • 1
    • 4
  • Yukari Takase
    • 1
  • Daisuke Mori
    • 1
  • Osamu Tokunaga
    • 1
  • Akihiko Nakashima
    • 2
  • Minoru Shigemori
    • 3
  1. 1.Department of Pathology and Biodefense, Faculty of MedicineSaga UniversitySagaJapan
  2. 2.Department of PathologyFukuoka Saisekai General HospitalFukuokaJapan
  3. 3.Departments of NeurosurgeryKurume University School of MedicineKurume, FukuokaJapan
  4. 4.Department of PathologyKurume University School of MedicineKurume, FukuokaJapan

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