Journal of Neuro-Oncology

, Volume 82, Issue 1, pp 81–83 | Cite as

Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma

  • Marc C. Chamberlain
  • Michael J. Glantz
  • Lisa Chalmers
  • Alixis Van Horn
  • Andrew E. Sloan
Clinical-Patient Studies

Abstract

Concurrent temozolomide (TMZ) and radiotherapy is the new standard of care for patients with newly diagnosed glioblastoma. In 51 consecutive patients treated according to this regimen, 7 patients (14%) manifested surgically confirmed early necrosis without evidence of recurrent tumor. This observation suggests that daily TMZ may represent a potent radiosensitizing regimen.

Keywords

Glioblastoma Temodar Radiotherpy 

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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Marc C. Chamberlain
    • 1
  • Michael J. Glantz
    • 2
  • Lisa Chalmers
    • 1
  • Alixis Van Horn
    • 2
  • Andrew E. Sloan
    • 1
  1. 1.Department of Interdisciplinary OncologyH. Lee Moffitt Cancer Center and Research InstituteTampaUSA
  2. 2.Department of Neurology and OncologyUniversity of Massachusetts Medical CenterWorcesterUSA

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