Journal of Neuro-Oncology

, Volume 80, Issue 3, pp 251–259

S100A13, a new marker of angiogenesis in human astrocytic gliomas

  • M. Landriscina
  • G. Schinzari
  • G. Di Leonardo
  • M. Quirino
  • A. Cassano
  • E. D’Argento
  • L. Lauriola
  • M. Scerrati
  • I. Prudovsky
  • C. Barone
Laboratory Investigation

DOI: 10.1007/s11060-006-9189-y

Cite this article as:
Landriscina, M., Schinzari, G., Di Leonardo, G. et al. J Neurooncol (2006) 80: 251. doi:10.1007/s11060-006-9189-y

Abstract

S100 proteins are Ca2+-binding polypeptides involved in the tumourigenesis of several human neoplasms. S100A13 is a key regulator of the stress-dependent release of FGF1, the prototype of the FGF protein family involved in angiogenesis. Indeed, S100A13 is a copper binding protein able to enhance the export of FGF1 in response to stress in vitro and to induce the formation of a multiprotein aggregate responsible for FGF1 release. We investigated the expression of S100A13 in human astrocytic gliomas in␣relation to tumour grading and vascularization. A series of 26 astrocytic gliomas was studied to evaluate microvessel density and to assess FGF1, S100A13 and VEGF-A expression. FGF1 was equally expressed in the vast majority of tumours, whereas S100A13 and VEGF-A were significantly up-regulated in high-grade vascularized gliomas. Moreover, both S100A13 and VEGF-A expression significantly correlated with microvessel density and tumour grading. These data suggest that the up-regulation of S100A13 and VEGF-A expression correlates with the activation of angiogenesis in high-grade human astrocytic gliomas.

Keywords

Angiogenesis Brain tumours FGF1 S100A13 Tumour grading VEGF-A 

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • M. Landriscina
    • 1
  • G. Schinzari
    • 2
  • G. Di Leonardo
    • 2
  • M. Quirino
    • 2
  • A. Cassano
    • 2
  • E. D’Argento
    • 2
  • L. Lauriola
    • 3
  • M. Scerrati
    • 4
  • I. Prudovsky
    • 5
  • C. Barone
    • 2
    • 6
  1. 1.Clinical Oncology Unit, Department of Medical Sciences University of Foggia FoggiaItaly
  2. 2.Clinical Oncology Unit, Department of Internal Medicine Catholic University RomeItaly
  3. 3.Department of Pathology Catholic UniversityRomeItaly
  4. 4.Department of Neurosurgery University of Ancona AnconaItaly
  5. 5.Center for Molecular Medicine Maine Medical Center Research Institute ScarboroughUSA
  6. 6.Oncologia MedicaUniversità Cattolica del S. CuoreRoma Italy

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