Female predominance in meningiomas can not be explained by differences in progesterone, estrogen, or androgen receptor expression
- 279 Downloads
The female predominance in meningioma incidence and association between meningioma and breast cancer suggest that growth of meningiomas is hormone-dependent. There are several discrepancies in literature about the proliferative effect of sex hormones on meningiomas. This study aims to evaluate the hormone receptor status of meningiomas and assess its relation to age, sex, histological grade, recurrence, and proliferation activity. The material was based on consecutive patients operated for meningioma at Tampere University Hospital in 1989–1999. The occurrence of progesterone, estrogen and androgen receptor in patients with primary and recurrent meningiomas was studied immunohistochemically by using specific monoclonal antibodies. Hormonal status was determined in 510 tumor samples. 443 samples were from primary meningiomas and 67 from recurrent tumors. Of the␣samples, 455 were benign (WHO grade I), 49 atypical (grade II), and 6 malignant (grade III). Of the primary tumor samples, 88% were progesterone receptor positive, 40% were positive for estrogen and 39% for androgen receptors. Grade I meningiomas had significantly higher incidence for estrogen and androgen receptors than higher grade meningiomas. Estrogen positive tumor samples had significantly higher proliferation index than estrogen negative samples. No difference in expression of sex hormone receptors was observed by sexes or age group. Estrogen and androgen receptors may have more influence on the pathogenesis of meningiomas than earlier thought. The higher incidence of meningiomas in women can not be␣explained by differences of sex hormone receptor expression.
KeywordsAndrogen receptor Estrogen receptor Meningioma MIB-1 Progesterone receptor
Unable to display preview. Download preview PDF.
We thank Sari Toivola, Salla Kolmihaara, Paula Kaukoranta, and Anssi Lagerstedt for their excellent techincal assistance.
- 5.Black P, Carroll R, Zhang J (1996) The molecular biology of hormone and growth factor receptors in meningiomas. Acta Neurochir 65(Suppl):50–53Google Scholar
- 7.Bouillot P, Pellissier JF, Devictor B, Graziani N, Bianco N, Grisoli F, Figarella-Branger D (1994) Quantitative imaging of estrogen and progesterone receptors, estrogen-regulated protein, and growth fraction: immunocytochemical assays in 52 meningiomas. Correlation with clinical and morphological data. J Neurosurg 81:765–773PubMedGoogle Scholar
- 10.Carrol RS, Glowacka D, Dashner K, Black PM (1993) Progesterone receptor expression in meningiomas. Cancer Res 53:1312–1316Google Scholar
- 11.Carrol RS, Zhang J, Dashner K, Sar M, Wilson EM, Black P (1995) Androgen receptor expression in meningiomas. J Neurosurg 82:453–460Google Scholar
- 14.Carrol RS, Brown M, Zhang J, DiRenzo J, Font de Mora J, Black PM (2000) Expression of a subset of steroid receptor cofactors is associated with progesterone receptor epression in meningiomas. Clin Cancer Res 6:3570–3575Google Scholar
- 46.Roelvinck NCA, Kamphorst W, van Alphen HAM, Rao R (1987) Pregnancy-related primary brain and spinal tumors. Arch Neurol 44:209–215Google Scholar