Intracranial tumors in adult population of the Varaždin County (Croatia) 1996–2004: a␣population-based retrospective incidence study
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To estimate the incidence of intracranial tumors in the adult population of the Varaždin County, Croatia, for the 1996–2004 period.
Setting: Varaždin County General Hospital and four university hospitals in Zagreb, the capital of Croatia. Study period: January 1, 1996 to December 31, 2004. Incident patients: county residents admitted for newly diagnosed intracranial tumors according to the WHO diagnostic criteria. Demographic data were extracted from the 2001 Croatian census. Incidence rates (IRs) per 100,000 person-years (p-y) and annual IRs (per 100,000 persons) were determined and compared as incidence rate ratios (IRRs) with 95% CI.
For primary intracranial tumors (PITs), IR was 12.1/100,000 p-y (95% CI: 10.3–14.2), comparable in men and women. The highest incidence was recorded for glioblastoma (IR 4.8, 3.7–6.2) and meningioma (IR 3.1, 2.2–4.2). The incidence of PIT was somewhat greater than that of metastatic tumors (IRR 1.58, 95% CI: 1.22–2.05, P<0.001). Metastatic tumors were more frequent in men than in women, especially metastatic lung tumors (IRR 6.08, 2.32–20.16, P<0.001). IRs of all PIT taken together, neuroepithelial tumors cumulatively, nonepithelial tumors cumulatively, glioblastoma and meningioma were higher in the population aged ≥40 vs. population aged ≤ 39 (all IRRs with 95% CI greater than 1, P<0.05 or < 0.001), comparable in men and women. Women were somewhat older than men at the time of diagnosis of PIT: median difference −6 years (95.1% CI: −10 to −1, P<0.05). Annual IRs for all these tumor categories showed increasing trends over the study period.
Overall, there was an increasing trend in the incidence of primary intracranial tumors in the Varaždin County. Data did not allow estimation for most of the specific tumor types.
Key words:intracranial tumors Croatia epidemiology
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- 2.Kaye SH, Laws ER Jr: Gliomas. In: Kaye AH, Laws ER Jr (eds) Brain Tumors. Churchill Livingstone, Edinburgh, pp 433–560, 1995Google Scholar
- 7.Mao Y, Desmeules M, Semenciw RM, Hill G, Gaudette L, Wigle DT 1991 Increasing brain cancer rates in CanadaCan Med Assoc J 145: 1583–1591Google Scholar
- 11.CBTRUS (2004). Statistical report: Primary brain tumors in the United States Statistical Report 1997–2001. Published by the Central Brain Tumor Registry of the United StatesGoogle Scholar
- 13.Shibamoto Y, Tsuchida E, Seki K, Oya N, Hasegawa M, Toda Y, Takemoto M, Sumi M, Hiratsuka J, Oguchi M, Hosono M, Yasuda S, Sougawa M, Kakutoh Y, Hayabuchi N 2004 Primary central nervous system lymphoma in Japan 1995–1999: changes from the preceding 10 yearsJ Cancer Res Clin Oncol 130(6): 351–356CrossRefPubMedGoogle Scholar
- 14.van der Sanden GA, Schouten LJ, van Dijck JA, van Andel JP, van der Maazen RW, Coebergh JW 2002 Working Group of Specialists in Neuro-Oncology in the Southern and Eastern Netherlands: primary central nervous system lymphomas: incidence and survival in the Southern and Eastern NetherlandsCancer 94(5): 1548–1556CrossRefPubMedGoogle Scholar
- 15.Materljan E, Materljan B, Sepčič J, Tuškan-Mohar L, Zamolo G, Erman-Baldini I 2004 Epidemiology of central nervous system tumors in Labin area, Croatia,1974–2001Croatian Med J 45(2): 206–212Google Scholar
- 16.Cancer incidence in Croatia. Bulletins No. 13–23. Zagreb: Croatian National Institute of Public Health; 1993–2001Google Scholar
- 17.Census of population, households and dwellings, March 31, 2001. Population by sex and age, by settlements. Available at: http://www.dzs.hr. Accessed: February 1, 2005Google Scholar