Journal of Neuro-Oncology

, Volume 78, Issue 3, pp 303–310

Intracranial tumors in adult population of the Varaždin County (Croatia) 1996–2004: a␣population-based retrospective incidence study

  • Biserka Dobec-Meić
  • Slaven Pikija
  • Danijel Cvetko
  • Vladimir Trkulja
  • Leo Pažanin
  • Nenad Kudelić
  • Krešimir Rotim
  • Ivan Pavliček
  • and Ruža Kostanjevec
Clinical--patient studies

Summary

Aim

To estimate the incidence of intracranial tumors in the adult population of the Varaždin County, Croatia, for the 1996–2004 period.

Methods

Setting: Varaždin County General Hospital and four university hospitals in Zagreb, the capital of Croatia. Study period: January 1, 1996 to December 31, 2004. Incident patients: county residents admitted for newly diagnosed intracranial tumors according to the WHO diagnostic criteria. Demographic data were extracted from the 2001 Croatian census. Incidence rates (IRs) per 100,000 person-years (p-y) and annual IRs (per 100,000 persons) were determined and compared as incidence rate ratios (IRRs) with 95% CI.

Results

For primary intracranial tumors (PITs), IR was 12.1/100,000 p-y (95% CI: 10.3–14.2), comparable in men and women. The highest incidence was recorded for glioblastoma (IR 4.8, 3.7–6.2) and meningioma (IR 3.1, 2.2–4.2). The incidence of PIT was somewhat greater than that of metastatic tumors (IRR 1.58, 95% CI: 1.22–2.05, P<0.001). Metastatic tumors were more frequent in men than in women, especially metastatic lung tumors (IRR 6.08, 2.32–20.16, P<0.001). IRs of all PIT taken together, neuroepithelial tumors cumulatively, nonepithelial tumors cumulatively, glioblastoma and meningioma were higher in the population aged ≥40 vs. population aged ≤ 39 (all IRRs with 95% CI greater than 1, P<0.05 or < 0.001), comparable in men and women. Women were somewhat older than men at the time of diagnosis of PIT: median difference −6 years (95.1% CI: −10 to −1, P<0.05). Annual IRs for all these tumor categories showed increasing trends over the study period.

Conclusion

Overall, there was an increasing trend in the incidence of primary intracranial tumors in the Varaždin County. Data did not allow estimation for most of the specific tumor types.

Key words:

intracranial tumors Croatia epidemiology 

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References

  1. 1.
    Kleihues P, Burger PC, Scheithauer BW 1996 The new WHO classification of brain tumoursBrain Pathol 3: 255–268CrossRefGoogle Scholar
  2. 2.
    Kaye SH, Laws ER Jr: Gliomas. In: Kaye AH, Laws ER Jr (eds) Brain Tumors. Churchill Livingstone, Edinburgh, pp 433–560, 1995Google Scholar
  3. 3.
    Dȁ8Alessandro G, Di Giovanni M, Ianizzi L, Guidetti E, Bottachi E 1995 Neuroepidemiology of primary intracranial tumors in the Valle dȁ8Aosta (Italy) during the 6-year period 1986–1991Neuroepidemiology 14: 139–146PubMedCrossRefGoogle Scholar
  4. 4.
    Christensen HC, Kosteljanetz M, Johansen C 2003 Incidence of gliomas and meningiomas in Denmark, 1943 to 1997Neurosurgery 52: 1327–1334CrossRefPubMedGoogle Scholar
  5. 5.
    Counsell CE, Collie DA, Grant R 1996 Incidence of intracranial tumours in the Lothian region of Scotland, 1989–1990J Neurol Neurosurg Psychiatry 61: 143–150PubMedCrossRefGoogle Scholar
  6. 6.
    Posner JB, Chernik NL 1978 Intracranial metastases from systemic cancerAdv Neurol 19: 579–592PubMedGoogle Scholar
  7. 7.
    Mao Y, Desmeules M, Semenciw RM, Hill G, Gaudette L, Wigle DT 1991 Increasing brain cancer rates in CanadaCan Med Assoc J 145: 1583–1591Google Scholar
  8. 8.
    Helseth A, 1993 Increasing incidence of primary central nervous system tumors in the elderly: real increase or improved detection?J Natl Cancer Inst 85:1871–1872PubMedCrossRefGoogle Scholar
  9. 9.
    Gurney JG, Kadan-Lottick N 2001 Brain and other central nervous system tumors: rates, trends and epidemiologyCurr Opin Oncol 13: 160–166CrossRefPubMedGoogle Scholar
  10. 10.
    Shugg D, Allen BJ, Blizzard L, Dwyer T, Roder D 1994 Brain cancer incidence, mortality and case survival from two Australian cancer registriesInt J Cancer 59: 765–770PubMedCrossRefGoogle Scholar
  11. 11.
    CBTRUS (2004). Statistical report: Primary brain tumors in the United States Statistical Report 1997–2001. Published by the Central Brain Tumor Registry of the United StatesGoogle Scholar
  12. 12.
    Pobereskin LH, Chadduck JB 2000 Incidence of brain tumours in two English counties: a population based studyJ Neurol Neurosurg Psychiatr 69: 464–471CrossRefPubMedGoogle Scholar
  13. 13.
    Shibamoto Y, Tsuchida E, Seki K, Oya N, Hasegawa M, Toda Y, Takemoto M, Sumi M, Hiratsuka J, Oguchi M, Hosono M, Yasuda S, Sougawa M, Kakutoh Y, Hayabuchi N 2004 Primary central nervous system lymphoma in Japan 1995–1999: changes from the preceding 10 yearsJ Cancer Res Clin Oncol 130(6): 351–356CrossRefPubMedGoogle Scholar
  14. 14.
    van der Sanden GA, Schouten LJ, van Dijck JA, van Andel JP, van der Maazen RW, Coebergh JW 2002 Working Group of Specialists in Neuro-Oncology in the Southern and Eastern Netherlands: primary central nervous system lymphomas: incidence and survival in the Southern and Eastern NetherlandsCancer 94(5): 1548–1556CrossRefPubMedGoogle Scholar
  15. 15.
    Materljan E, Materljan B, Sepčič J, Tuškan-Mohar L, Zamolo G, Erman-Baldini I 2004 Epidemiology of central nervous system tumors in Labin area, Croatia,1974–2001Croatian Med J 45(2): 206–212Google Scholar
  16. 16.
    Cancer incidence in Croatia. Bulletins No. 13–23. Zagreb: Croatian National Institute of Public Health; 1993–2001Google Scholar
  17. 17.
    Census of population, households and dwellings, March 31, 2001. Population by sex and age, by settlements. Available at: http://www.dzs.hr. Accessed: February 1, 2005Google Scholar
  18. 18.
    Preston-Martin S, 1996 Epidemiology of primary CNS neoplasmsNeurol Clin 14:273–290CrossRefPubMedGoogle Scholar
  19. 19.
    Parkin DM, Muir CS 1992 Cancer incidence in five continentsIARC Sci Publ 120: 45–173PubMedGoogle Scholar
  20. 20.
    Fogelholm R, Uutela T, Murros K 1995 Epidemiology of central nervous system neoplasms. A regional survey in Central Finland J Neurosurg 83: 999–1003PubMedCrossRefGoogle Scholar
  21. 21.
    Klos KJ, Oȁ8Neill BP 2004 Brain metastases Neurologist 10(1): 31–46CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Biserka Dobec-Meić
    • 1
  • Slaven Pikija
    • 2
    • 8
  • Danijel Cvetko
    • 3
  • Vladimir Trkulja
    • 4
  • Leo Pažanin
    • 5
  • Nenad Kudelić
    • 6
  • Krešimir Rotim
    • 7
  • Ivan Pavliček
    • 2
  • and Ruža Kostanjevec
    • 2
  1. 1.Department of RadiologyJordanovac University Hospital for Pulmonary DiseasesZagrebCroatia
  2. 2.Department of NeurologyVaraždin General HospitalVaraždinCroatia
  3. 3.Department of RadiologyVaraždin General HospitalVaraždinCroatia
  4. 4.Department of Pharmacology, School of MedicineUniversity of ZagrebZagrebCroatia
  5. 5.Department of NeuropathologyZagreb University Hospital CenterZagrebCroatia
  6. 6.University Department of NeurosurgerySestre Milosrdnice University HospitalZagrebCroatia
  7. 7.University Department of NeurosurgeryDubrava University HospitalZagrebCroatia
  8. 8.Djelatnost za neurologijuOpća bolnica VaraždinVaraždinCroatia

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