Radiation induced meningioma with a short latent period following high dose cranial irradiation – Case report and literature review
Radiation induced meningiomas (RIM) are rare late complications in patients who have received high dose irradiation for brain tumors. The mean latency period for induction of RIM in most of the series is 18.7±10.2 years. There are only 9 reported cases of RIM following high dose cranial irradiation with unusually short latency periods of less than 5 years. Herein, we report a child diagnosed with RIM with an unusually short latency period of 14 months. An 11-year old male child underwent gross total resection of medulloblastoma. Following surgery he received high dose craniospinal irradiation. Postoperative computed tomography scan (CT scan) after 1 month did not show features of any residual tumor, recurrence or tumor at a new site. The child was asymptomatic for 14 months and then presented with complaints of headache and vomiting. CT scan head showed multiple solid homogenously enhancing lesions in bilateral basifrontal and right basitemporal region. Histopathology of the lesions turned out to be atypical meningioma.
Keywordscranial irradiation medulloblastoma multiple meningiomas radiation induced meningioma radiation induced tumors radiation therapy second neoplasm
Unable to display preview. Download preview PDF.
- 1.Lacassagne A, 1933 Condition dans lesquelles ont ete obtenus, chez le lapin, des cancers par action des rayons X sur des foyer inflammetories Compt Rend Soc Biol 112: 562–564Google Scholar
- 13.Mack EE, Wilson CB 1993 Meningiomas induced by high-dose cranial irradiation J Neurosurrg 79: 28–31Google Scholar
- 16.Horanyi B, 1965 Roentgen-besugarzas hatasara Keletkezett meningeoma gyermeken Magyar Radiol 17: 1–7Google Scholar
- 21.Duffner PK, Krischer JP, Horowitz ME, Cohen ME, Burger PC, Friedman HS, Kun LE, 1998 Second malignancies in young children with primary brain tumors following treatment with prolonged postoperative chemotherapy and delayed irradiation: a Pediatric Oncology Group study Ann Neurol 44: 313–316CrossRefPubMedGoogle Scholar