Journal of Neuro-Oncology

, Volume 71, Issue 2, pp 161–168 | Cite as

Semi-quantification of methionine uptake and flair signal for the evaluation of chemotherapy in low-grade oligodendroglioma

  • Bich-Ngoc-Thanh Tang
  • Niloufar Sadeghi
  • Fabrice Branle
  • Olivier De Witte
  • David Wikler
  • Serge Goldman
Clinical Study


11C-Methionine (MET) is a useful positron emission tomography (PET) tracer for the evaluation of low-grade gliomas. Among these tumors, a high percentage of low-grade oligodendrogliomas (ODG) are sensitive to chemotherapy with procarbazine, CCNU, and vincristine (PCV). We aimed at: (1) objectively assessing ODG response to PCV by a metabolic index (the Activity Volume Index or AVI) generated from an automated semi-quantification of PET with MET (PET-MET); (2) comparing AVI and quantitative magnetic resonance imaging (MRI) measurements of response to PCV.

Methods: seven patients with ODG were followed for a period of 19.9±6.6months after the completion of PCV chemotherapy. Regions of interest (ROI) were generated by covering all voxels with count values above a threshold level set at 120% of the mean cerebellar activity. On each slice, ROI volume and mean count values were calculated. AVI was calculated as the sum over all ROI of tumor volume×(tumor mean count/cerebellum count). Tumor volume measurements on MRI, were based on signal abnormalities visually detected on fluid-attenuated inversion recovery (FLAIR) sequences.

Results: PCV therapy was associated with a drastic decrease in AVI (mean±SD, cm3): AVI post-PCV=0.80±1.45 vs. AVI prior PCV=12.94±11.46 (P=0.03). Likewise, we observed a decrease in tumor volume estimated from the FLAIR signal (31.37±11.99 post-PCV vs. 67.95±39.96 prior PCV, P=0.03) although AVI decrease after PCV was significantly more pronounced (P=0.015).

Conclusion: This study, based on limited number of patients and follow-up period indicates that AVI may be a sensitive and observer-independent method applicable to the assessment of ODG responsiveness to PCV treatment and may offer a major added value to both clinical assessment and MRI evaluation of chemotherapeutic outcomes.


11C-methionine oligodendrogliomas PCV chemotherapy positron emission tomography 


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Copyright information

© Springer 2005

Authors and Affiliations

  • Bich-Ngoc-Thanh Tang
    • 1
    • 5
  • Niloufar Sadeghi
    • 2
  • Fabrice Branle
    • 3
  • Olivier De Witte
    • 4
  • David Wikler
    • 1
  • Serge Goldman
    • 1
  1. 1.Department of Nuclear Medicine and PET/Biomedical-Cyclotron UnitUniversité Libre de Bruxelles-Hôpital ErasmeBrusselsBelgium
  2. 2.Department of RadiologyUniversité Libre de Bruxelles-Hôpital ErasmeBrusselsBelgium
  3. 3.Department of OncologyUniversité Libre de Bruxelles-Hôpital ErasmeBrusselsBelgium
  4. 4.Department of NeurosurgeryUniversité Libre de Bruxelles-Hôpital ErasmeBrusselsBelgium
  5. 5.Hospital ErasmeBrusselsBelgium

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