Journal of Neuro-Oncology

, Volume 74, Issue 2, pp 195–199

Growth Retardation and Bilateral Cataracts Followed by Anaplastic Meningioma 23 Years after High-Dose Cranial and Whole-Body Irradiation for Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

  • Alexei I. Korenkov
  • Hans G. Imhof
  • Sebastian Brandner
  • Ethan Taub
  • Pia U. Huguenin
  • Michael R. Gaab
  • Yasuhiro Yonekawa
Clinical Study

Summary

We report a case of meningioma diagnozed 23 years after high-dose cranial and whole-body irradiation for the treatment of acute lymphocytic leukemia (ALL). Radiotherapy in this case also caused early radiation injury to the lenses and the pituitary gland, with growth retardation and mineralizing angiopathy. Radiation-induced meningiomas are more commonly malignant, more commonly multiple, and more likely to recur after resection than non-radiation-induced meningiomas. Survivors of childhood ALL treated with high-dose cranial irradiation are at risk both for early radiation injury in radiosensitive organs, such as the lens and pituitary gland, and for the later development of a radiation-induced meningioma.

Keywords

acute lymphocytic leukemia anaplastic meningioma growth retardation posterior subcapsular cataract radiation therapy 

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Copyright information

© Springer 2005

Authors and Affiliations

  • Alexei I. Korenkov
    • 1
  • Hans G. Imhof
    • 2
  • Sebastian Brandner
    • 3
  • Ethan Taub
    • 4
  • Pia U. Huguenin
    • 5
  • Michael R. Gaab
    • 1
  • Yasuhiro Yonekawa
    • 2
  1. 1.Department of NeurosurgeryUniversity GreifswaldGreifswaldGermany
  2. 2.Department of NeurosurgeryUniversity ZuerichZuerichSwitzerland
  3. 3.Department of NeuropathologyUniversity ZuerichZuerichSwitzerland
  4. 4.Gamma Knife ZentrumKlinik Im ParkSwitzerland
  5. 5.Department of RadiotherapyUniversity ZuerichZuerichSwitzerland

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