Journal of Neuro-Oncology

, Volume 74, Issue 1, pp 53–57

Osseous metastasis of pineoblastoma: a case report and review of the literature

  • Claire Constantine
  • Douglas C. Miller
  • Sharon Gardner
  • Casilda Balmaceda
  • Jonathan Finlay
Clinical Study


Purpose: To review the literature on the occurrence of osseous metastases in recurrent pineoblastoma, and to report upon the feasibility and efficacy of treatment using intensive conventional chemotherapy to achieve a remission, followed by consolidation with marrow ablative chemotherapy and autologous hemopoietic stem cell rescue. Patient and Methods:An adult with isolated extraneural, osseous and bone marrow metastases from a pineoblastoma, received conventional cyclical chemotherapy, followed by consolidation with marrow ablative chemotherapy (thiotepa, carboplatin and temozolomide) and autologous hemopoietic stem cell rescue. Results: A complete radiographic and histopathologic response was achieved after almost one year of conventional chemotherapy that was tolerated without significant sequelae. Following successful harvesting of peripheral blood stem cells, the patient underwent myeloablative chemotherapy with autologous stem cell rescue, without difficulty in hemopoietic reconstitution and without serious or permanent side effects. Conclusions: Osseous metastases from pineoblastoma are an extremely rare occurrence. We conclude that conventional chemotherapy can achieve a complete response, and subsequent consolidation with marrow ablative chemotherapy and autologous hemopoietic stem cell rescue is feasible and well tolerated.


myeloablative chemotherapy osseous metastasis pineoblastoma 


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  1. 1.
    Fauchon, F, Jouvet, A, Pauis, P, Saint-Pierre, G, Mottolese, C, Ben Hassel, M, Chauveinc, L, Sichez, JP, Philippon, J, Schlienger, M, Bouffet, E 2000Parenchymal pineal tumors: a clinicopathological study of 76 casesInt J Radiat Oncol Biol Phys46959968CrossRefPubMedGoogle Scholar
  2. 2.
    Sutherland, GR, Florell, R, Louw, D, Choi, NW, Sims, AA,  et al. 1987Epidemiology of primary intracranial neoplasms in Manitoba, CanadaCan J Neurol Sci14586592PubMedGoogle Scholar
  3. 3.
    Schweitzer T, Vince GH, Herbold C, Roosen K, Tonn J-C (2001) Extra-neural metastases of primary brain tumors. J Neuro-oncol 54: 107–114Google Scholar
  4. 4.
    Banerjee, AK, Kak, VK 1974Pineoblastoma with spontaneous intra and extracranial metastasisJ Pathol114912CrossRefPubMedGoogle Scholar
  5. 5.
    Jacobs, JJ, Rosenberg, AE 1989Extracranial skeletal metastasis from pineoblastoma. A case report and review of the literatureClin Orthop247256260PubMedGoogle Scholar
  6. 6.
    Fraser, G, Rampling, R, Smith, C, Nicoll, J, Stephen, M 2000Long-term survival following extra-neural metastasis from a pineoblastomaJ Neurooncol48141144CrossRefPubMedGoogle Scholar
  7. 7.
    Charafe-Jauffret, E, Lehmann, G, Fauchon, F, Michiels, JF, Paquis, P, Maranchinchi, D, Hassoun, J 2001Vertebral metastases from pineoblastomaArch Pathol Lab Med125939943PubMedGoogle Scholar
  8. 8.
    Rosenfeld, JV, Murphy, MA, Chow, CW 1990Implantation metastasis of pineoblastoma after stereotactic biopsyA case report. J␣Neurosurg73287290Google Scholar
  9. 9.
    Gururangan, S, Heidemann, RL, Kovnar, EH, Sanford, RA, Kun, LE 1994Peritoneal metastases in two patients with pineoblastoma and ventriculo-peritoneal shuntsMed Pediatr Oncol22417420PubMedGoogle Scholar
  10. 10.
    Kawanami, H, Takahashi, M, Tanaka, M. 1971Metastasis of pineal tumor with special reference to x-ray findingsRinsho Hoshasen16564575PubMedGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Claire Constantine
    • 1
  • Douglas C. Miller
    • 2
  • Sharon Gardner
    • 1
  • Casilda Balmaceda
    • 3
  • Jonathan Finlay
    • 4
  1. 1.Department of PediatricsNew York University of School of MedicineNew York
  2. 2.Pathology (Division of Neuropathology)New York University School of MedicineNew York
  3. 3.Neurological InstituteColumbia UniversityNew York
  4. 4.Neural Tumors ProgramChildrens Center for Cancer and Blood Diseases, Childrens HospitalLos Angeles

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