Journal of Neuro-Oncology

, Volume 71, Issue 2, pp 189–193 | Cite as

Intraventricular tanycytic ependymoma: case report and review of the literature

  • Brian T. Ragel
  • Jeannette J. Townsend
  • Adam S. Arthur
  • William T. Couldwell
Clinical study

Abstract

Objective and importance:Tanycytic ependymomas are a rare ependymoma subtype showing a marked predilection for the spine, with only a few reports of supratentorial tumors. We present a case of a tanycytic ependymoma arising from the lateral and third ventricle.

Clinical presentation: The patient was a 55-year-old woman who complained of intermittent, progressively worsening dysequilibrium for several months. The neurologic exam in the neurosurgery clinic was without deficit.

Intervention: MRI of the brain revealed a 3-cm, minimally enhancing lesion centered in the superior aspect of the third ventricle. The tumor involved the left wall of the third ventricle, the septum pellucidum, and the anterior horn of the left lateral ventricle. Surgery was recommended for diagnosis and to prevent obstructive hydrocephalus. A gross total resection was achievedvia a transcallosal approach. Postoperatively, the patient remained neurologically intact.

Conclusion:The long-term prognosis for tanycytic ependymomas is the same or slightly better than for other ependymoma subtypes. The current treatment plan includes gross total resection followed by radiologic surveillance. Repeat resection or radiation treatment will be recommended in the event of recurrence.

Keywords

supratentorial tumors tanycytic ependymoma 

Abbreviations

EM

electron microscopy

GFAP

glial fibrillary acidic protein

H&E

hematoxylin and eosin

NF-2

neurofibromatosis type-2

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References

  1. Wiestler, OD, Schiffer, D, Coons, SW, Prayson, RA, Rosenblum, MK 2000

    Ependymal Tumours

    Kleihues, PCavenee, WK eds. Pathology and Genetics of Tumours of the Nervous SystemInternational Agency for Research on Cancer (IARC) PressLyon, France7277
    Google Scholar
  2. Daneyemez, M, Can, C, Izci, Y, Beduk, A, Timuckaynak, E 1999The tanycytic ependymoma of the lateral ventricle: case reportMinim Invasive Neurosurg42201203Google Scholar
  3. Hayashi, S, Kameyama, S, Fukuda, M, Takahashi, H 2000Ganglioglioma with a tanycytic ependymoma as the glial componentActa Neuropathol (Berl)99310316Google Scholar
  4. Burger, PC, Scheithauer, BW, Vogel, FS 2002

    The Brain: Tumors

    Burger, PCScheithauer, BWVogel, FS eds. Surgical Pathology of the Nervous System and its CoveringsChurchill LivingstonePhiladelphia241250
    Google Scholar
  5. Langford, LA, Barre, GM 1997Tanycytic ependymomaUltrastruct Pathol21135142Google Scholar
  6. Louis, DN, Stemmer-Rachamimov, AO, Wiestler, OD 2000

    Neurofibromatosis type 2

    Kleihues, PCavenee, WK eds. Pathology and Genetics of Tumours of the Nervous SystemInternational Agency for Research on Cancer (IARC) PressLyon, France219222
    Google Scholar
  7. ME, Alonso, MJ, Bello, D, Arjona, P, Gonzalez Gomez, J, Lomas, JM, de Campos, ME, Kusak, A, Isla, JA, Rey 2002Analysis of the NF2 gene in oligodendrogliomas and ependymomasCancer Genet Cytogenet13415CrossRefPubMedGoogle Scholar
  8. Birch, BD, Johnson, JP, Parsa, A, Desai, RD, Yoon, JT, Lycette, CA, Li, YM, Bruce, JN 1996Frequent type 2 neurofibromatosis gene transcript mutations in sporadic intramedullary spinal cord ependymomasNeurosurgery39135140Google Scholar
  9. Ebert, C, von Haken, M, Meyer-Puttlitz, B, Wiestler, OD, Reifenberger, G, Pietsch, T, von Deimling, A 1999Molecular genetic analysis of ependymal tumors NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas.Am J Pathol155627632Google Scholar
  10. Rubio, MP, Correa, KM, Ramesh, V, MacCollin, MM, Jacoby, LB, von Deimling, A, Gusella, JF, Louis, DN 1994Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomasCancer Res544547Google Scholar
  11. von Haken, MS, White, EC, Daneshvar Shyesther, L, Sih, S, Choi, E, Kalra, R, Cogen, PH 1996Molecular genetic analysis of chromosome arm 17p and chromosome arm 22q DNA sequences in sporadic pediatric ependymomasGenes Chromosomes Cancer173744Google Scholar
  12. Pollack IF, Gerszten PC, Martinez AJ, Lo KH, Shultz B, Albright AL, Janosky J, Deutsch M: Intracranial ependymomas of childhood: long-term outcome and prognostic factors. Neurosurgery 37: 655–666; discussion 666–657, 1995Google Scholar
  13. Robertson, PL, Zeltzer, PM, Boyett, JM, Rorke, LB, Allen, JC, Geyer, JR, Stanley, P, Li, H, Albright, AL, McGuire-Cullen, P, Finlay, JL, Stevens, KR, Milstein, JM, Packer, RJ, Wisoff, J 1998Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Children’s Cancer GroupJ Neurosurg88695703Google Scholar
  14. Schwartz, TH, Kim, S, Glick, RS, Bagiella, E, Balmaceda, C, Fetell, MR, Stein, BM, Sisti, MB, Bruce, JN 1999Supratentorial ependymomas in adult patientsNeurosurgery44721731Google Scholar
  15. Suzuki, S, Oka, H, Kawano, N, Tanaka, S, Utsuki, S, Fujii, K 2001Prognostic value of Ki-67 (MIB-1) and p53 in ependymomasBrain Tumor Pathol18151154Google Scholar
  16. Prayson, RA 1998Cyclin D1 and MIB-1 immunohistochemistry in ependymomas: a study of 41 casesAm J Clin Pathol110629634PubMedGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Brian T. Ragel
    • 1
  • Jeannette J. Townsend
    • 2
  • Adam S. Arthur
    • 1
  • William T. Couldwell
    • 1
    • 3
  1. 1.Department of NeurosurgeryUniversity of Utah Health Sciences CenterUSA
  2. 2.Department of PathologyUniversity of Utah Health Sciences CenterSalt Lake CityUSA
  3. 3.Department of NeurosurgeryUniversity of UtahSalt Lake CityUSA

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