Age-Related Features of α-Synuclein Pathology in the Brain on Modeling the Preclinical Stage of Parkinson’s Disease in Rats
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The pathomorphological signs of Parkinson’s disease (PD), an untreatable neurodegenerative condition, include the formation of pathological α-synuclein-positive inclusions in neurons. Studies using a model of the preclinical stage of PD in middle-aged and elderly rats based on increasing suppression of brain proteasome activity, along with analysis by light and confocal microscopy, addressed the presence and locations of pathological α-synuclein-positive inclusions in dopaminergic neurons in the compact part of the substantia nigra (SNc) and olfactory bulb. In the model of BP, α-synuclein aggregates were located in the cytoplasm of dopaminergic neurons in the olfactory bulb and the cytoplasm and nuclei of dopaminergic neurons in the SNc. A characteristic feature of α-synuclein pathology in aging rats was deposition of larger α-synuclein aggregates in the bodies of nerve cells in these locations as compared with middle-aged rats.
KeywordsParkinson’s disease lactacystin α-synuclein aggregates substantia nigra olfactory bulb aging rats
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