Neuroscience and Behavioral Physiology

, Volume 48, Issue 8, pp 978–982 | Cite as

Habituation of Somatosensory Event-Related Potentials in Subthreshold Rhythmic (1 Hz) Electrocutaneous Stimulation of the Arm during the Slow-Wave Stage of Daytime Sleep

  • V. B. DorokhovEmail author
  • Yu. V. Ukraintseva
  • G. N. Arsen’ev
  • A. Yu. Mironov
  • I. P. Trapeznikov
  • O. N. Tkachenko
  • V. V. Dementienko

Previous studies have shown that low-frequency subthreshold electrocutaneous stimulation of the arm during deep slow-wave sleep in humans improves sleep quality. The main cognitive processes are known to operate during sleep, and use of event-related potentials is the main method for analysis of these processes. The aims of the present work were to study the characteristics of somatosensory event-related potentials (sERP) on rhythmic (1 Hz) subthreshold electrocutaneous volley stimulation of the arm during the slow-wave stage of daytime sleep and to evaluate the potential for habituation of sERP to rhythmic stimulation during sleep. Subthreshold stimulation during sleep produced somatosensory event-related potentials (ERP) (group mean, n = 16) in which three long-latency components could be identifi ed, which were more marked in the frontal lead of the contralateral hemisphere. Comparison of sERP averaged from the beginning and end of the volley of stimuli (30 stimuli) demonstrated signifi cant decreases in the amplitudes of all sERP components by the end of the volley. It is suggested that the decrease in sERP amplitude in slow-wave sleep is due to the simplest form of stimulus-dependent nonassociative learning - habituation.


sleep subthreshold rhythmic stimulation habituation somatosensory event-related potentials 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    V. B. Dorokhov and Yu. S. Verbitskaya, “Dynamics of components of auditory long-latency event-related potentials at different stages of slow-wave sleep,” Zh. Vyssh. Nerv. Deyat. I. P. Pavlova, 55, No. 1, 29 –38 (2005).Google Scholar
  2. 2.
    E. V. Verbitskii and I. A. Topchii, “Habituation of event-related potentials in people with high, moderate, and low anxiety,” Zh. Vyssh. Nerv. Deyat. I. P. Pavlova, 55, No. 4, 514–517 (2005).Google Scholar
  3. 3.
    P. A. Indurskii, V. V. Markelov, V. M. Shakhnarovich, and V. B. Dorokhov, “Low-frequency electrocutaneous stimulation of the wrist during the slow-wave stage of nocturnal sleep: physiological and therapeutic effects,” Fiziol. Cheloveka, 399, No. 6, 91–105 (2013).Google Scholar
  4. 4.
    E. N. Sokolov, Perception and Conditioned Reflexes, Moscow State University Press, Moscow (1958).Google Scholar
  5. 5.
    K. Campbell, D. S. Michaud, S. E. Keith, A. Muller-Gass, and S. Wiebe, “Event-related potential measures of the disruptive effects of trains of auditory stimuli during waking and sleeping states,” J. Sleep Res., 14, No. 4, 347–357 (2005).CrossRefGoogle Scholar
  6. 6.
    K. Campbell and A. Muller-Gass, “The extent of processing of near-hearing threshold stimuli during natural sleep,” Sleep, 34, No. 9, 1243–1249 (2011).CrossRefGoogle Scholar
  7. 7.
    H. Firth, “Habituation during sleep,” Psychophysiology, 10, No. 1, 43–51 (1973).CrossRefGoogle Scholar
  8. 8.
    A. M. Ibácez, R. S. Martín, E. Hurtado, and V. López, “ERPs studies of cognitive processing during sleep,” Int. J. Psychol., 44, No. 4, 290–304 (2009).CrossRefGoogle Scholar
  9. 9.
    M. Massimini, M. Rosanova, and M. Mariotti, “EEG slow (1 Hz) waves are associated with nonstationarity of thalamo-cortical sensory processing in the sleeping human,” J. Neurophysiol., 89, No. 3, 1205–1213 (2003).CrossRefGoogle Scholar
  10. 10.
    H. V. Ngo, J. C. Claussen, J. Born, and M. Molle, “Induction of slow oscillations by rhythmic acoustic stimulation,” J. Sleep Res., 22, No. 1, 22–31 (2013).CrossRefGoogle Scholar
  11. 11.
    C. S. Poon and D. L. Young, “Nonassociative learning as gated neural integrator and differentiator in stimulus-response pathways,” Behav. Brain Funct., 2, 29 (2006).CrossRefGoogle Scholar
  12. 12.
    R. F. Thompson, P. M. Groves, T. J. Teyler, and R. A. Roemer, “A dual-process theory of habituation: theory and behavior,” in: Habituation, H. V. S. Peeke and M. J. Herz (eds.), Academic Press, New York (1973), Vol. 1, pp. 239–271.CrossRefGoogle Scholar
  13. 13.
    G. Tononi and C. Cirelli, “Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration,” Neuron, 81, No. 1, 12–34 (2014).CrossRefGoogle Scholar
  14. 14.
    B. van Sweden, J. G. van Dijk, and J. F. Caekebeke, “Auditory information processing in sleep: habituation to repetitive stimuli,” Neuropsychobiology, 30, No. 2–3, 143–147 (1994).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • V. B. Dorokhov
    • 1
    Email author
  • Yu. V. Ukraintseva
    • 1
  • G. N. Arsen’ev
    • 1
  • A. Yu. Mironov
    • 1
  • I. P. Trapeznikov
    • 1
  • O. N. Tkachenko
    • 1
  • V. V. Dementienko
    • 2
  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia
  2. 2.Kotelnikov Institute of Radio Engineering and ElectronicsRussian Academy of SciencesMoscowRussia

Personalised recommendations