Characteristics of Single-Unit and Network Activity of Neurons in the Subthalamic Nucleus on Production of Impulsive and Delayed (self-controlled) Responses in Conditions of Reinforcement Choice
- 19 Downloads
Experiments on cats addressed neuron activity in the subthalamic nucleus (STN) during different types of behavior in a situation of choosing reinforcement in relation to its value and availability. Chronic experiments were performed to record neuron activity in the subthalamic nucleus and orbitofrontal cortex and to analyze neuron activity in terms of frequency and network properties. Neurons in the subthalamic nucleus were found to respond with acceleration or suppression of discharge activity to both the conditioned stimulus and reinforcements of different value. However, a given subthalamic nucleus neuron could respond with increases in activity frequency to the expectation of a bread/meat mix and a decrease in the activity frequency to expectation of meat. The number of cross-correlational excitatory links between neurons in the subthalamic nucleus was found to be significantly greater in when the choice was for impulsive behavior than for self-controlled behavior. The number of cross-correlational links between cells in the orbitofrontal cortex and subthalamic nucleus with intervals over the range 0–30 msec was significantly greater on appearance of impulsive than self-controlled behavior. The electrophysiological results obtained here provide support for the suggestion that the STN is involved in organizing networks associated with taking decisions regarding selection of impulsive or self-controlled behavior.
Keywordsbehavior impulsivity neuron interneuronal interactions reinforcement choice
Unable to display preview. Download preview PDF.
- Bukh-Viner, L. V., Volkov, I. V., and Merzhanova G. Kh., “Spike collector,” Zh. Vyssh. Nerv. Deyat., 40, No. 6, 1194–1199 (1990).Google Scholar
- Zaichenko, M. I. and Merzhanova G. Kh., “Studies of the manifestations of impulsivity in rats in a situation of choosing food reinforcements of different values,” Zh. Vyssh. Nerv. Deyat, 60, No. 1, 56–64 (2010).Google Scholar
- Merzhanova, G. Kh. and Berg, A. M., “Selection of reinforcement quality depending on the delay time of operant animals in cats,” Zh. Vyssh. Nerv. Deyat., 41, No. 5, 948–954 (1991).Google Scholar
- Merzhanova, G. Kh., Kuleshova, E. L., and Grigor’yan, G. A., “Organi zation of ‘impulsive’ behavior using a time counting model,” Zh. Vyssh. Nerv. Deyat., 56, No. 6, 805–812 (2006).Google Scholar
- Sidorina, V. V., Kuleshova, E. P., and Merzhanova, G. Kh., “The activity of cortical and dorsal striatal neurons in animals in a ‘right to choose’ food reinforcement situation,” Zh. Vyssh. Nerv. Deyat., 63, No. 2, 269–279 (2013).Google Scholar
- Baunez, C., Christakou, A., Chudasama, Y., et al., “Bilateral high-frequency stimulation of the subthalamic nucleus on attentional performance: transient deleterious effects and enhanced motivation in both intact and parkinsonian rats,” Eur. J. Neurosci., 25, No. 4, 1187–1194 (2007).CrossRefPubMedPubMedCentralGoogle Scholar
- Baunez, C. and Lardeux S., “Frontal cortex-like functions of the subthalamic nucleus,” Front Syst. Neurosci., No. 5, 83 (2011).Google Scholar
- Merzhanova, G. Kh., “Impulsivity and self-control in animals and humans during choice of behavioral strategy,” in: Psychology of Impulsivity, M. A. Cyders (ed.), Nova (2012)., No. 6, pp. 183–209.Google Scholar
- Reinoso-Suarez, F., Topographischer Hirnatlas der Katze (für experimental-physiologische Untersuchungen), Darmstadt (1961).Google Scholar
- Winstanley, C. A., Baunez, C., Theobald, D. E., and Robbins T. W., “Lesions to the subthalamic nucleus decrease impulsive choice but impair autoshaping in rats: the importance of the basal ganglia in Pavlovian conditioning and impulse control,” Eur. J. Neurosci., 21, 3107–3116 (2005).CrossRefPubMedGoogle Scholar