Gender-Dependent Actions of the Histone Deacetylase Blocker Sodium Valproate on Olfactory Learning in 129Sv Mice during the Early Postnatal Period
- 50 Downloads
The processes of histone acetylation in the brain underlie both the mechanisms supporting the long-term stable effects of early experience, transmitted to offspring generations by epigenetic inheritance, and learning. However, the role of acetylation in learning has previously been studied only in adult animals: high levels of learning can be linked with high levels of histone H3 acetylation in the brain. The role of acetylation processes in the mechanisms of early learning has not been addressed. We report here our studies of the effects of blockade of histone deacetylation with sodium valproate, which increases the level of acetylation of histone H3, on the outcome of training to olfactory discrimination in 8-day-old mice of strain 129Sv, which have low levels of learning with simulation of maternal grooming. Four doses of sodium valproate, given from day 3 to day 6 of postnatal development, were found to have gender-dependent actions: there were selective improvements in learning in males but not females, though females showed this seen after repeated administration of physiological saline. The possible epigenetic mechanisms underlying these gender-related differences are discussed.
Keywordsolfactory learning ontogeny histone H3 acetylation blockade of histone deacetylases sodium valproate gender-related differences epigenetics
Unable to display preview. Download preview PDF.
- 1.E. A. Aleksandrova, I. Yu. Zaraiskaya, and K. V. Anokhin, “Comparative analysis of the formation of behavior in mice of two inbred strains,” in: Behavior and Behavioral Ecology of Mammals, KMK, Moscow (2005), pp. 349–351.Google Scholar
- 2.O. V. Burenkova, E. A. Aleksandrova, and I. Yu. Zaraiskaya, “Deprivation of 129Sv mouse offspring of their mothers in early ontogeny improves olfactory learning with simulation of maternal grooming,” Byull. Eksperim. Biol. Med., 153, No. 5, 724–726 (2012).Google Scholar
- 3.A. V. Lobanov, O. N. Khokhlova, L. A. Zakharova, et al., “A model for analysis of neurotoxic actions on embryonic development in terms of assessment of somatosensory maturation in mice,” Toksikol. Vestn., No. 2, 22–25 (2008).Google Scholar