Neuroscience and Behavioral Physiology

, Volume 42, Issue 6, pp 575–581 | Cite as

Targeted Inactivation of the Gene Encoding Gamma-Synuclein Affects Anxiety Levels and Investigative Activity in Mice

  • V. S. KokhanEmail author
  • A. V. Bolkunov
  • A. A. Ustiugov
  • G. I. Van’kin
  • T. A. Shelkovnikova
  • O. M. Redkozubova
  • T. V. Strekalova
  • V. L. Buchman
  • N. N. Ninkina
  • S. O. Bachurin

Gamma (γ) synuclein is a member of the family of synucleins, which are cytoplasmic, predominantly, neuronal, proteins found only in vertebrates. Significant quantities of γ-synuclein are found in the axons and presynaptic terminals of neurons located in brain areas responsible for forming emotions and memory. However, the involvement of γ-synucleins in controlling neuronal and synaptic processes underlying various types of behavior in humans and animals have not yet been studied. We provide the first demonstration that the absence of γ-synuclein increases orientational-investigative activity in a novel context and decreases the level of situational anxiety in animals.


γ-synuclein knockout mouse genetically modified animals anxiety behavior 


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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • V. S. Kokhan
    • 1
    Email author
  • A. V. Bolkunov
    • 1
  • A. A. Ustiugov
    • 1
  • G. I. Van’kin
    • 1
  • T. A. Shelkovnikova
    • 1
  • O. M. Redkozubova
    • 1
  • T. V. Strekalova
    • 1
  • V. L. Buchman
    • 2
  • N. N. Ninkina
    • 1
    • 2
  • S. O. Bachurin
    • 1
  1. 1.Institute of Physiologically Active Substances, Russian Academy of SciencesChernogolovkaRussia
  2. 2.Cardiff UniversityCardiffUK

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