Induction of Amnesia Evoked by Impairment to Memory Reconsolidation by Glutamate or Serotonin Receptor Antagonists Is Suppressed by Protein Synthesis Inhibitors
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Common snails previously trained to an associative skill consisting of refusing a defined foodstuff were used to study the effects of the ionotropic AMPA-kainate glutamate receptor antagonist DNQX, the serotonin receptor antagonist methiothepin, and the protein synthesis inhibitor cycloheximide on long-term memory reconsolidation processes. DNQX and cycloheximide given 24 h after training and before a reminder procedure were found to lead to impairment of the reproduction of the acquired skill, which was not restored by retraining two weeks after initial training. The skill impaired after methiothepin and the reminder recovered on retraining. However, simultaneous injections of DNQX and cycloheximide or methiothepin and cycloheximide before the reminder produced no impairment to the skill. It is suggested that irreversible and reversible types of amnesia induced by AMPA-kainate glutamate receptor antagonists and serotonin antagonists respectively require the synthesis of specific protein molecules.
Keywordslearning memory reconsolidation amnesia neurotransmitter receptors protein synthesis inhibitors common snail
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