Induction of Amnesia Evoked by Impairment to Memory Reconsolidation by Glutamate or Serotonin Receptor Antagonists Is Suppressed by Protein Synthesis Inhibitors
Common snails previously trained to an associative skill consisting of refusing a defined foodstuff were used to study the effects of the ionotropic AMPA-kainate glutamate receptor antagonist DNQX, the serotonin receptor antagonist methiothepin, and the protein synthesis inhibitor cycloheximide on long-term memory reconsolidation processes. DNQX and cycloheximide given 24 h after training and before a reminder procedure were found to lead to impairment of the reproduction of the acquired skill, which was not restored by retraining two weeks after initial training. The skill impaired after methiothepin and the reminder recovered on retraining. However, simultaneous injections of DNQX and cycloheximide or methiothepin and cycloheximide before the reminder produced no impairment to the skill. It is suggested that irreversible and reversible types of amnesia induced by AMPA-kainate glutamate receptor antagonists and serotonin antagonists respectively require the synthesis of specific protein molecules.
Keywordslearning memory reconsolidation amnesia neurotransmitter receptors protein synthesis inhibitors common snail
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- 1.M. S. Abramova, V. L. Nistratova, A. A. Moskvitin, and A. S. Pivovarov, “Methiothepin-sensitive serotonin receptors are involved in the postsynaptic mechanism of sensitization of defensive reactions in the common snail,” Zh. Vyssh. Nerv. Deyat. Google Scholar
- 2.S. V. Solntseva and V. P. Nikitin, “Serotonin and NMDA glutamate receptor antagonists selectively impair reactivation of associative memory in the common snail,” Ros. Fiziol. Zh. im. I. M. Sechenova, 93, No. 10, 1101–1111 (2007).Google Scholar
- 3.S. V. Solntseva and V. P. Nikitin, “The reversible and irreversible stages of the development of amnesia after impairment of the reactivation of associative memory in snails,” Zh. Vyssh. Nerv. Deyat., 59, No. 3, 344–352 (2009).Google Scholar
- 4.S. V. Solntseva and V. P. Nikitin, “Protein synthesis is required for the induction of amnesia arising on impairment of the reconsolidation of long-term memory,” Ros. Fiziol. Zh. im. I. M. Sechenova, 96, No. 3, 247–258 (2010).Google Scholar
- 5.S. V. Solntseva and V. P. Nikitin, S. A. Kozyrev, A. V. Shevelkin, A.V. Lagutin, and V. V. Sherstnev, “Inhibition of protein synthesis during reactivation of an associative memory in the common snail induces transient or irreversible amnesia,” Ros. Fiziol. Zh. im. I. M. Sechenova, 92, No. 9, 1058–1068 (2006).Google Scholar
- 8.K. V. Anokhin, A. A. Tiunova, and S. P. R. Rose, “Reminder effects – reconsolidation or retrieval deficit? Pharmacological dissection with protein synthesis inhibitors following reminder for a passive-avoidance task in young chicks,” Eur. J. Neurosci., 15, No. 11, 1759–1765 (2002).PubMedCrossRefGoogle Scholar
- 9.P. M. Balaban, “Declarative and procedural memory in animals with simple nervous systems,” in: Psychology at the Turn of the Millennium, C. Hofsten (ed.), Akad. Press, Stockholm (2002), Vol. 1, pp. 1–28.Google Scholar
- 10.A. Citri and R. C. Malenka, “Synaptic plasticity: multiple forms, functions, and mechanisms,” Neuropsychopharmacology Rev., 1–24 (2007).Google Scholar