Recovery of Memory by the Glutamate NMDA Receptor Agonist D-Cycloserine Depends on the Stage of Development of Amnesia
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We have previously observed that in common snails trained to an associative skill consisting of refusing a defined foodstuff, impairment of memory reconsolidation by the NMDA receptor antagonist MK-801 evokes amnesia in which the skill can be recovered by retraining at the early stage (<10 days) while retraining at the late stage does not lead to formation of the skill. In the experiments reported here, amnesia was induced with MK-801 and a reminder 24 h after training of snails to conditioned taste aversion, and the antiamnestic effects of D-cycloserine, a partial agonist of the glycine site of the NMDA receptor, were studied in the early (day 3) and late (day 12) stages. Three days after induction of amnesia, injections of D-cycloserine and a reminder of the conditioned food stimulus led to recovery of the memory; administration of D-cycloserine without a subsequent reminder was ineffective. Injection of D-cycloserine and a reminder 12 days after induction of amnesia had no effect on its development and retraining did not lead to recovery of the memory. Thus, this study is the first to show that the NMDA receptor agonist D-cycloserine influences memory recovery processes only at the early stage of development of amnesia induced by lesioning of reconsolidation processes, while the late stage of amnesia was not sensitive to this agonist.
Keywordslearning long-term memory reconsolidation amnesia NMDA glutamate receptors D-cycloserine common snail
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- 1.N. I. Dubrovina, D. R. Zinoviev, and D. V. Zinovieva, “N-methyl-Daspartate receptors and amnesia in mice with a depression-like state,” Byull. Eksperim. Biol. Med., 144, No. 11, 484–486 (2007).Google Scholar
- 2.S. A. Kozyrev and V. P. Nikitin, “Neuronal mechanisms of the reactivation of an associative aversive skill to food in the common snail,” Ros. Fiziol. Zh. im. I. M. Sechenova, 95, No. 6, 652–662 (2009).Google Scholar
- 3.S. V. Solntseva and V. P. Nikitin, “Serotonin and NMDA glutamate receptor antagonists selectively impair the reactivation of associative memory in the common snail,” Ros. Fiziol. Zh. im. I. M. Sechenova, 93, No. 10, 1101–1111 (2007).Google Scholar
- 4.S. V. Solntseva and V. P. Nikitin, “The reversible and irreversible stages of the development of amnesia after impairment of the reactivation of an associative memory in snails,” Zh. Vyssh. Nerv. Deyat., 59, No. 2, 232–241 (2009).Google Scholar
- 5.S. V. Solntseva and V. P. Nikitin, “Effects of NMDA glutamate and serotonin receptor agonists at different stages of amnesia induced by impairment to the reconsolidation of long-term memory,” Neirokhimiya, 27, No. 3 (2010).Google Scholar
- 7.K. V. Anokhin, A. A. Tiunova, and S. P. R. Rose, “Reminder effects – reconsolidation or retrieval deficit? Pharmacological dissection with protein synthesis inhibitors following reminder for a passiveavoidance task in young chicks,” Eur. J. Neurosci., 15, No. 11, 1759–1765 (2002).PubMedCrossRefGoogle Scholar
- 8.P. M. Balaban, “Declarative and procedural memory in animals with simple nervous systems,” in: Psychology at the Turn of the Millennium, S. Hofsten (ed.), Akad. Press, Stockholm (2002), No. 1, pp. 1–28.Google Scholar
- 9.A. Biegon, M. Alvarado, T. F. Budinger, R. Grossman, K. Hensley, M. S. West, Y. Kotake, M. Ono, and R. A. Floyd, “Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain,” J. Neurochem., 82, No. 4, 924–934 (2002).PubMedCrossRefGoogle Scholar
- 10.A. Biegon, P. A. Fry, C. M. Paden, A. Alexandrovich, J. Tsenter, and E. Shohami, “Dynamic changes in N-methyl-d-aspartate receptors after closed head injury in mice: Implications for treatment of neurological and cognitive deficits,” Proc. Natl. Acad. Sci. USA, 101, No. 14, 5117–5122 (2004).PubMedCrossRefGoogle Scholar
- 13.L. K. Friedman, M. D. Ginsberg, L. Belayev, R. Busto, O. F. Alonso, B. Lin, and M. Y. Globus, “Intraischemic but not postischemic hypothermia prevents non-selective hippocampal downregulation of AMPA and NMDA receptor gene expression after global ischemia,” Mol. Brain Res., 86, No. 1–2, 34–47 (2001).PubMedCrossRefGoogle Scholar
- 29.R. Yaka, A. Biegon, N. Grigoriadis, C. Simeonidou, S. Grigoriadis, A. G. Alexandrovich, H. Matzner, J. Scheumann, V. Trembovler, J. Tsenter, and E. Shohami, “D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury,” FASEB J., 21, No. 9, 2033–2041 (2007).PubMedCrossRefGoogle Scholar