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Morphogenesis of the Epidural Space in Humans during the Embryonic and Early Fetal Periods

  • A. A. RodionovEmail author
  • R. I. Asfandiyarov
Article

The development of the epidural space was studied on 51 series of sections from embryos and early fetuses aged from four to 13 weeks using histological and embryological methods for plastic and graphic reconstruction. We found that three stages can be discriminated in the development of the epidural space: I) the primary epidural space (embryos of 16–31 mm crown-rump length (CRL); II) reduction of the primary epidural space (embryos of 35–55 mm CRL); and III) the secondary epidural space (embryos of 60–70 mm CRL and fetuses of 80–90 mm CRL). The morphogenesis of the primary epidural space is determined by the formative influence of the spinal cord and its dura mater, while that of the secondary epidural space is determined by the walls of the vertebral canal. In the spinal cord-dura mater of the spinal cord-vertebral canal correlation system, the latter two components, subjected to the inducing influence of the first, determine the morphogenesis of the epidural space via a system of morphogenetic correlations. The correlational relationships are apparent as time-linked connections between the rudiment of the dura mater of the spinal cord and the vertebral canal, resulting in the stage-by-stage formation of the epidural space in the ventrodorsal and craniocaudal directions. These same morphogenetic correlations also determine the staging of the development of the epidural space.

Key words

spinal cord dura mater of the spinal cord epidural space morphogenesis 

References

  1. 1.
    P. P. Ivanov, Handbook of General and Comparative Embryology [in Russian], Medgiz, Leningrad (1945).Google Scholar
  2. 2.
    B. Carlson, Patten’s Foundation of Embryology [Russian translation], Mir, Moscow (1983), Vol. 1.Google Scholar
  3. 3.
    S. I. Lebedkin, “Changes in the lengths of spinal cord segments and the axial skeleton during development in humans and pigs,” Izv. Nauchn. Inst. im. P. F. Lesgafta, 20, No. 2, 13–94 (1936).Google Scholar
  4. 4.
    I. N. Petrovskii, Epidural Veins of the Vertebral Canal (An Anatomical Experimental Investigation) [in Russian], Author’s Abstract of Thesis for Doctorate in Medicine, Simferopol (1984).Google Scholar
  5. 5.
    N. V. Popova-Latkina, “Analysis of topographic anatomical correlations between the brain and spinal cord, skull, and vertebrae, their interaction, and their mutual influences on each other in human embryogenesis,” in: Functional-Structural Bases of Systems Activity and the Mechanisms of Brain Plasticity [in Russian], Meditsina, Moscow (1975), pp. 278–281.Google Scholar
  6. 6.
    A. V. Rumyantsev, Experience in Studies of the Evolution of Cartilaginous and Bone Tissue [in Russian], Medgiz, Moscow (1958).Google Scholar
  7. 7.
    P. G. Svetlov, Physiology (Mechanics) of Development [in Russian], Nauka, Leningrad (1978), Vol. 2.Google Scholar
  8. 8.
    A. N. Severtsov, Morphological Features of Evolution [in Russian], Medgiz, Moscow, Leningrad (1939).Google Scholar
  9. 9.
    P. E. Snesarev, “Embryological development of the meninges in relation to the genesis of meningothelioma and primary sarcomas of the brain,” Vopr. Neirokhir., 3, No. 1–3, 25–44 (1939).Google Scholar
  10. 10.
    M. S. Spirov, “Embryogenesis of the human meninges,” Arkh. Anat., 9, No. 2, 229 (1933).Google Scholar
  11. 11.
    L. I. Falin, Human Embryology: An Atlas [in Russian], Meditsina, Moscow (1976).Google Scholar
  12. 12.
    D. A. Shamburov, The Cerebrospinal Fluid [in Russian], Medgiz, Moscow (1954).Google Scholar
  13. 13.
    I. I. Shmal’gauzen, The Body as a Whole in Individual and Historical Development. Selected Works [in Russian], Nauka, Moscow (1982).Google Scholar
  14. 14.
    M. Hamid, C. Fallet-Bianco, V. Delmas, and O. Plaisant, “The human lumbar anterior epidural space: morphological comparison in adult and fetal specimens,” Surg. Radiol. Anat., 24, 194–200 (2002).CrossRefPubMedGoogle Scholar
  15. 15.
    M. Ludinghausen and P. Dzillas, “Zur Entwicklung des menschlichen Epiduralraumes,” Anat. Anz., 5, 571–584 (1972).Google Scholar
  16. 16.
    M. Patelska-Banaszeska and W. Wozniak, “The development of the epidural space in human embryos,” Folia Morphol. (Warszawa), 63, No. 3, 273–279 (2004).Google Scholar
  17. 17.
    T. R. Ursu, R. W. Porter, and V. Navartnam, “Development of the lumbar and sacral vertebral canal in utero,” Spine, 21, No. 23, 2705–2708 (1996).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  1. 1.Department of Human Anatomy (Director: Professor A. A. Rodionov)Amur State Medical AcademyBlagoveshchenskRussia
  2. 2.Department of Human Anatomy (Director: Professor R. I. Asfandiyarov)Astrakhan State Medical AcademyAstrakhanRussia

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