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Neuroscience and Behavioral Physiology

, Volume 37, Issue 5, pp 489–493 | Cite as

Resistance of the myocardium to ischemia and the efficacy of ischemic preconditioning in experimental diabetes mellitus

  • M. M. Galagudza
  • M. K. Nekrasova
  • A. V. Syrenskii
  • E. M. Nifontov
Article

Abstract

Data on the influences of diabetes mellitus on the severity of ischemic damage to the myocardium are contradictory. We report here experiments using a model based on in vivo myocardial infarcts resulting from coronary occlusion to study the resistance of the myocardium in rats with alloxan-induced insulin-dependent diabetes mellitus to prolonged ischemia, along with studies of the infarct-limiting efficacy of ischemic preconditioning. The results showed that after diabetes mellitus for six weeks, the relative size of infarcts was significantly less than in controls (39.8 ± 8.8 and 62.3 ± 6.6% of the size of the anatomical risk zone respectively, p < 0.01). In addition, animals with diabetes mellitus developed ischemic ventricular tachyarrhythmia significantly less often than controls. A single episode of ischemic preconditioning in animals with diabetes mellitus had a less marked infarct-limiting effect than the same procedure in controls. Thus, these data support the existence of an endogenous cardioprotective phenotype (metabolic preconditioning) in experimental diabetes. On the other hand, the efficacy of ischemic preconditioning was sharply decreased in diabetes.

Key words

heart ischemia myocardial infarct preconditioning diabetes mellitus 

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References

  1. 1.
    N. N. Petrishchev, E. V. Shlyakhto, T. D. Vlasov, and M. M. Galagudza, “Ischemic adaptation of the myocardium: pathophysiological mechanisms and possible potentials for practical application (literature review),” Ros. Fiziol. Zh. im. I. M. Sechenova, 87, No. 5, 688–705 (2001).Google Scholar
  2. 2.
    S. Bakth, J. Arena, W. Lee, R. Torres, B. Haider, B. C. Patel, M. M. Lyons, and T. J. Regan, “Arrhythmia susceptibility and myocardial composition in diabetes. Influence of physical conditioning,” J. Clin. Invest., 77, No. 2, 382–395 (1986).PubMedGoogle Scholar
  3. 3.
    D. Feuvray and G. D. Lopaschuk, “Controversies on the sensitivity of the diabetic heart to ischemic injury: the sensitivity of the diabetic heart to ischemic injury is decreased,” Cardiovasc. Res., 34, No. 1, 113–120 (1997).PubMedCrossRefGoogle Scholar
  4. 4.
    R. Forrat, L. Sebbag, N. Wiernsperger, J. Guidollet, S. Renaud, and M. de Lorgeril, “Acute myocardial infarction in dogs with experimental diabetes,” Cardiovasc. Res., 27, No. 11, 1908–1912 (1993).PubMedGoogle Scholar
  5. 5.
    G. Hadour, R. Ferrera, L. Sebbag, R. Forrat, J. Delaye, and M. de Lorgeril, “Improved myocardial tolerance to ischaemia in the diabetic rabbit,” J. Mol. Cell. Cardiol., 30, No. 9, 1869–1875 (1998).PubMedCrossRefGoogle Scholar
  6. 6.
    A. M. Murcia, C. H. Hennekens, G. A. Lamas, M. Jimenez-Navarro, J. L. Rouleau, G. C. Flaker, S. Goldman, H. Skali, E. Braunwald, and M. A. Pfeffer, “Impact of diabetes on mortality in patients with myocardial infarction and left ventricular dysfunction,” Arch, Intern. Med., 164, No. 20, 2273–2279 (2004).CrossRefGoogle Scholar
  7. 7.
    C. E. Murry, R. B. Jennings, and K. A. Reimer, “Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium,” Circulation, 74, No. 5, 1124–1136 (1986).PubMedGoogle Scholar
  8. 8.
    D. J. Paulson, “The diabetic heart is more sensitive to ischemic injury,” Cardiovasc. Res., 34, No. 1, 104–112 (1997).PubMedCrossRefGoogle Scholar
  9. 9.
    T. Ravingerova, J. Neckar, and F. Kolar, “Ischemic tolerance of rat hearts in acute and chronic phases of experimental diabetes,” Mol. Cell. Biochem., 249, No. 1–2, 164–174 (2003).Google Scholar
  10. 10.
    T. Ravingerova, R. Stetka, D. Pancza, O. Ulicna, A. Ziegelhoffer, and J. Styk, “Susceptibility to ischemia-induced arrhythmias and the effect of preconditioning in the diabetic rat heart,” Physiol. Res., 49, No. 5, 607–616 (2000).PubMedGoogle Scholar
  11. 11.
    P. H. Stone, J. E. Muller, T. Hartwell, B. J. York, J. D. Rutherford, C. B. Parker, Z. G. Turi, H. W. Strauss, J. T. Willerson, and T. Robertson, “The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infraction: contribution of both coronary disease and diastolic left ventricular dysfunction to the adverse prognosis. The MILIS Study Group,” Amer. J. Cell. Cardiol., 14, No. 1, 49–57 (1989).CrossRefGoogle Scholar
  12. 12.
    A. Tosaki, D. T. Engelman, R. M. Engelman, and D. K. Das, “The evolution of diabetic response to ischemia/reperfusion and preconditioning in isolated working rat hearts,” Cardiovasc. Res., 31, No. 4, 526–536 (1996).PubMedCrossRefGoogle Scholar
  13. 13.
    M. J. Walker, M. J. Curtis, D. J. Hearse, R. W. Campbell, M. J. Jance, D. M. Yellon, S. M. Cobbe, S. J. Coker, J. B. Harness, D. W. Harron, A. J. Higgins, D. G. Julian, M. L. Lab, A. S. Manning, B. J. Northover, J. R. Parratt, R. A. Riemersma, E. Riva, D. C. Russell, D. J. Sheridan, E. Winslow, and B. Woodward, “The Lambeth Conventions: guidelines for the study of arrhythmias in ischemia, infarction, and reperfusion,” Cardiovasc. Res., 22, No. 7, 447–455 (1988).PubMedCrossRefGoogle Scholar
  14. 14.
    D. M. Yellon and J. M. Downey, “Preconditioning the myocardium: from cellular physiology to clinical cardiology,” Physiol. Rev., 83, No. 4, 1113–1151 (2003).PubMedGoogle Scholar
  15. 15.
    G. Zuanetti, R. Latini, A. P. Maggioni, L. Santoro, and M. G. Franzosi, “Influence of diabetes on mortality in acute myocardial infarction: data from the GISSI-2 study,” J. Amer. Cell. Cardiol., 22, No. 7, 1788–1794 (1993).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • M. M. Galagudza
    • 1
  • M. K. Nekrasova
    • 1
  • A. V. Syrenskii
    • 2
  • E. M. Nifontov
    • 1
  1. 1.I. P. Pavlov St. Petersburg State Medical UniversitySt. PetersburgRussia
  2. 2.V. A. Almazov Research Institute of CardiologyMinistry of Health and Social Development of the Russian FederationSt. PetersburgRussia

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