Neuroscience and Behavioral Physiology

, Volume 35, Issue 2, pp 139–146 | Cite as

Age-related changes in the characteristics of evoked responses in field CA1 in rat hippocampus slices after deafferentation of the forelimb

  • I. E. Kudryashov
  • I. V. Kudryashova
Article

Abstract

The effects of in situ transection of the median nerve in baby rats on the formation of the properties of synaptic transmission in the hippocampus were studied. Paired-pulse stimulation was used to identify the characteristics of short-term facilitation in living slices. Significant deviations in the time dynamics of facilitation from control values were seen in operated animals. Analysis showed that the decrease in the population spike amplitude, which we have described previously, may be due not only to functional causes, but also to morphological causes - elimination of neurons and their processes. It is suggested that a period of destructive changes is followed by the onset of a phase of intense formation of new synaptic contacts. The nature of the heterochrony of electrophysiological measures does not lead to any conclusion as to whether the maturation of intrahippocampal systems leads or lags in the experimental baby rats. It is suggested that hippocampal development along a new, abnormal pathway is induced.

KEY WORDS

ontogenesis hippocampal slices field CA1 population spikes synaptic efficiency paired-pulse facilitation 

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REFERENCES

  1. 1.
    I. E. Kudryashov and I. V. Kudryashova, “Possibilities for modifying development in early ontogenesis,” in: Proceedings of the XVIII Congress of the I. P. Pavlov Physiological Society [in Russian], Kazan’ (2001), p. 132.Google Scholar
  2. 2.
    Kudryashov, I. E., Kudryashova, I. V., Sitnikova, E. Yu., Raevskii, V. V. 1999Effects of deafferentation of the forelimb in early postnatal ontogenesis on the formation of synaptic transmission in the hippocampusZh. Vyssh. Nerv. Deyat.49629Google Scholar
  3. 3.
    Pigareva, M. L., Vorob’eva, A. D. 1994The anticipatory appearance of behavioral responses in baby rats subjected to sensory deprivationZh. Vyssh. Nerv. Deyat.44396Google Scholar
  4. 4.
    Asztely, F., Xiao, M.-Y., Gustafsson, B. 1996Long-term potentiation and paired-pulse facilitation in the hippocampal CA1 regionNeuroreport71609Google Scholar
  5. 5.
    Bekenstein, J. W., Lothman, E. W. 1991A comparison of the ontogeny of excitatory and inhibitory neurotransmission in the CA1 region and dentate gyrus of the rat hippocampal formationDevelopment.Brain Res.63237Google Scholar
  6. 6.
    DiScenna, P. G., Teyler, T. J. 1994Development of inhibitory and excitatory synaptic transmission in the rat dentate gyrusHippocampus4569Google Scholar
  7. 7.
    Harris, K. M., Teyler, T. J. 1983Evidence for late development of inhibition in area CA1 of the rat hippocampusBrain Res.268339Google Scholar
  8. 8.
    Janicke, R. U., Prengart, M. L., Wati, M. R., Porter, A. G. 1998Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosisJ. Biol. Chem.2739357Google Scholar
  9. 9.
    Katz, B., Miledi, R. 1968The role of calcium in neuromuscular facilitationJ. Physiol.195481Google Scholar
  10. 10.
    Kudryashov, I. E., Kudryashova, I. V. 2001Ontogeny of synaptic transmission in the rat hippocampusBrain Res.892263Google Scholar
  11. 11.
    Kudryashov, I. E., Onufriev, M. V., Kudryashova, I. V., Gulyaeva, N. V. 2001Periods of postnatal maturation of hippocampus: synaptic modifications and neuronal disconnectionDev. Brain Res.132113Google Scholar
  12. 12.
    Michelson, H. B., Lothman, E. W. 1989An in vivo electrophysiological study of the ontogeny of excitatory and inhibitory processes in the rat hippocampusDev. Brain Res.47113Google Scholar
  13. 13.
    Muller, D., Oliver, M., Lynch, G. 1989Developmental changes in synaptic properties in hippocampus of neonatal ratsDev. Brain Res.49105Google Scholar
  14. 14.
    Naruse, I., Keino, H. 1995Apoptosis in the developing CNSProgr. Neurobiol.47135Google Scholar
  15. 15.
    Pokorny, J., Yamamoto, T. 1981Postnatal ontogenesis of hippocampal CA1 area in ratsBrain Res. Bull.7113Google Scholar
  16. 16.
    Schultz, P. E., Cook, E. P., Johnston, D. 1994Changes in paired-pulse facilitation suggest presynaptic involvement in long-term potentiationJ. Neurosci.145325Google Scholar
  17. 17.
    Smith, B. N., Dudek, F. E. 2001Short-and long-term changes in CA1 network excitability after kainate treatment in ratsJ. Neurophysiol.851Google Scholar
  18. 18.
    Stringer, J. L., Lothman, E. W. 1992Ontogeny of hippocampal after-discharges in the urethane-anesthetized ratDevl. Brain Res.70223Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • I. E. Kudryashov
    • 1
  • I. V. Kudryashova
    • 1
  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscow

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