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Docetaxel-loaded biomimetic nanoparticles for targeted lung cancer therapy in vivo

  • Changliang Chi
  • Fuwei Li
  • Huibo Liu
  • Shiyun Feng
  • Yanjun Zhang
  • Da ZhouEmail author
  • Rongkui ZhangEmail author
Research Paper

Abstract

Although the nanodrug-loading system provides new ideas for the effective treatment of cancer, the lack of active cancer targeting, easy to be cleared by the reticuloendothelial system (RES), and may cause potential safety issues are still problems that needs urgent solution. Herein, the authors fabricated platelet membrane (PM)-coated docetaxel (DTX)-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles (PM/PLGA/DTX) that possessed unique advantages for satisfactory lung cancer therapy. The resulting core–shell nanoplatform exhibited proper size (hydrodynamic diameter was 98.2 nm) for the enhanced permeability and retention (EPR) effect, slowed down the release of loaded DTX, and effectively suppressed the growth of tumor cells in vitro. More importantly, due to the immune escape and cancer-targeting capacities of PM, the PM/PLGA/DTX showed long circulation and effective lung tumor-targeting ability. After administration in vivo antitumor activity, the PM/PLGA/DTX significantly inhibited the tumor growth of A549 cell-bearing nude mice. In addition, the PM/PLGA/DTX strongly reduced the DTX toxicity compared with that of free DTX. Therefore, the results here demonstrated this biomimetic nanoparticle is a promising nanosized drug delivery system for targeted lung cancer therapy.

Keywords

Platelet membrane Controlled drug delivery Targeted lung cancer therapy Docetaxel Biomimetic nanoparticles Drug toxicity PLGA Nanomedicine 

Notes

Funding information

The National Natural Science Foundation of China (no. 81362305) was gratefully acknowledged for financial support.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Urology SurgeryThe First Hospital of Jilin UniversityChangchunPeople’s Republic of China
  2. 2.Operating RoomChina-Japan Union Hospital of Jilin UniversityChangchunPeople’s Republic of China
  3. 3.Department of Dermatology and venereologyThe First Hospital of Jilin UniversityChangchunPeople’s Republic of China
  4. 4.Department of Thoracic SurgeryThe First Hospital of Jilin UniversityChangchunPeople’s Republic of China
  5. 5.Department of RadiologyThe First Hospital of Jilin UniversityChangchunPeople’s Republic of China

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